Literature DB >> 20845919

Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model.

Jonathan M Yuen, Nilam C Shah, Joseph T Walsh, Matthew R Glucksberg, Richard P Van Duyne.   

Abstract

This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.

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Year:  2010        PMID: 20845919      PMCID: PMC3031996          DOI: 10.1021/ac101951j

Source DB:  PubMed          Journal:  Anal Chem        ISSN: 0003-2700            Impact factor:   6.986


  28 in total

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