PURPOSE OF REVIEW: To review new clinically relevant data regarding the cause and treatment of scleritis that has been identified over the past 36 months. RECENT FINDINGS: A recently described T-helper cell population, known as Th-17, has been implicated in scleritis. Large-scale, retrospective reviews of standard corticosteroid-sparing systemic therapies, published in the last few years, have demonstrated only moderate efficacy for any particular immunomodulatory agent, whereas new data have confirmed excellent efficacy and tolerability to subconjunctival corticosteroids. SUMMARY: Improved understanding of the immunopathophysiology of scleritis offers hope for future molecule-specific drug design. Data continue to support the use of local steroids as a reasonable therapeutic option for nonnecrotizing, noninfectious anterior scleritis.
PURPOSE OF REVIEW: To review new clinically relevant data regarding the cause and treatment of scleritis that has been identified over the past 36 months. RECENT FINDINGS: A recently described T-helper cell population, known as Th-17, has been implicated in scleritis. Large-scale, retrospective reviews of standard corticosteroid-sparing systemic therapies, published in the last few years, have demonstrated only moderate efficacy for any particular immunomodulatory agent, whereas new data have confirmed excellent efficacy and tolerability to subconjunctival corticosteroids. SUMMARY: Improved understanding of the immunopathophysiology of scleritis offers hope for future molecule-specific drug design. Data continue to support the use of local steroids as a reasonable therapeutic option for nonnecrotizing, noninfectious anterior scleritis.
Authors: Tania Sales de Alencar de Fidelix; Luis Antonio Vieira; Denise de Freitas; Virginia Fernandes Moça Trevisani Journal: Int Ophthalmol Date: 2015-08-29 Impact factor: 2.031
Authors: Jared E Knickelbein; William R Tucker; Nirali Bhatt; Karen Armbrust; David Valent; Dominic Obiyor; Robert B Nussenblatt; H Nida Sen Journal: Am J Ophthalmol Date: 2016-09-20 Impact factor: 5.258