Rupesh Agrawal1,2,3, Cecilia S Lee1,4, Julio J Gonzalez-Lopez1,5, Sharmina Khan1, Valeria Rodrigues1, Carlos Pavesio1,2. 1. a Moorfields Eye Hospital , London , UK . 2. b Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology , London , UK . 3. c National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore . 4. d University of Washington , Seattle , Washington , USA , and. 5. e Surgery Department , Universidad de Alcalá School of Medicine , Madrid , Spain.
Abstract
OBJECTIVE: To analyze the safety and efficacy of a nonselective cyclo-oxygenase (COX) inhibitor in the management of noninfectious, non-necrotizing anterior scleritis. METHODS: Retrospective chart review of 126 patients with non-necrotizing anterior scleritis treated with oral flurbiprofen (Froben®(Abbott Healthcare)) with (Group B, n = 61) or without (Group A, n = 65) topical steroids was performed and time to remission was plotted. RESULTS: The observed incidence rate was 1.07 (95% CI: 0.57-1.99) per 1000 person-years with failure rate of 0.68 (95% CI: 0.22-2.12) per 1000 person-years in Group A and 1.41 (95% CI: 0.67-2.96) per 1000 person-years in Group B. The failure rate was 3.97 (1.89-9.34) per 1000 person-years with hazard ratio of 10.01 (95% CI: 2.52-39.65; p < 0.001) for patients with associated systemic disease. CONCLUSION: To the of our best knowledge, this is the first and largest case series on the safety and efficacy of a nonselective COX inhibitor in the management of anterior scleritis.
OBJECTIVE: To analyze the safety and efficacy of a nonselective cyclo-oxygenase (COX) inhibitor in the management of noninfectious, non-necrotizing anterior scleritis. METHODS: Retrospective chart review of 126 patients with non-necrotizing anterior scleritis treated with oral flurbiprofen (Froben®(Abbott Healthcare)) with (Group B, n = 61) or without (Group A, n = 65) topical steroids was performed and time to remission was plotted. RESULTS: The observed incidence rate was 1.07 (95% CI: 0.57-1.99) per 1000 person-years with failure rate of 0.68 (95% CI: 0.22-2.12) per 1000 person-years in Group A and 1.41 (95% CI: 0.67-2.96) per 1000 person-years in Group B. The failure rate was 3.97 (1.89-9.34) per 1000 person-years with hazard ratio of 10.01 (95% CI: 2.52-39.65; p < 0.001) for patients with associated systemic disease. CONCLUSION: To the of our best knowledge, this is the first and largest case series on the safety and efficacy of a nonselective COX inhibitor in the management of anterior scleritis.
Authors: Manjeet S Bhamra; Irfan Gondal; Abhimanyu Amarnani; Saul Betesh; Angelina Zhyvotovska; Wayne Scott; Milena Rodriguez-Alvarez; Douglas R Lazzaro; Isabel M McFarlane Journal: Int J Clin Res Trials Date: 2019-11-09