PURPOSE OF REVIEW: Chemotherapy is a cornerstone treatment in patients with early breast cancer. Although some cancer cell-related predictors are emerging, the indications of chemotherapy and the choice of chemotherapy regimen are not individualized enough, emphasizing the need for new predictors. This review will summarize recent advances concerning the implication of tumor microenvironment in the response to chemotherapy. RECENT FINDINGS: In recent years, some data have emerged suggesting that microenvironment could be involved in chemotherapy efficacy. The infiltration of tumor by lymphocytes has been highly correlated with the sensitivity to chemotherapy. These data are consistent with the discovery that anthracyclines could induce immune activation through immunogenic cell death. At the opposite, gene expression analyses have suggested that a stroma signature could predict resistance to neoadjuvant chemotherapy. Finally, chemotherapy has been shown to induce a spike of progenitors for endothelial cells, a mechanism that in turns mediates angiogenesis repopulation. SUMMARY: Preliminary data from pioneer studies suggest that tumor microenvironment could be involved in chemotherapy sensitivity and resistance. Such knowledge could generate two advances: simple predictors for chemotherapy efficacy based on pathology could be generated and strategies that aim at reversing drug resistance could be developed.
PURPOSE OF REVIEW: Chemotherapy is a cornerstone treatment in patients with early breast cancer. Although some cancer cell-related predictors are emerging, the indications of chemotherapy and the choice of chemotherapy regimen are not individualized enough, emphasizing the need for new predictors. This review will summarize recent advances concerning the implication of tumor microenvironment in the response to chemotherapy. RECENT FINDINGS: In recent years, some data have emerged suggesting that microenvironment could be involved in chemotherapy efficacy. The infiltration of tumor by lymphocytes has been highly correlated with the sensitivity to chemotherapy. These data are consistent with the discovery that anthracyclines could induce immune activation through immunogenic cell death. At the opposite, gene expression analyses have suggested that a stroma signature could predict resistance to neoadjuvant chemotherapy. Finally, chemotherapy has been shown to induce a spike of progenitors for endothelial cells, a mechanism that in turns mediates angiogenesis repopulation. SUMMARY: Preliminary data from pioneer studies suggest that tumor microenvironment could be involved in chemotherapy sensitivity and resistance. Such knowledge could generate two advances: simple predictors for chemotherapy efficacy based on pathology could be generated and strategies that aim at reversing drug resistance could be developed.
Authors: Stephanos Pavlides; Iset Vera; Ricardo Gandara; Sharon Sneddon; Richard G Pestell; Isabelle Mercier; Ubaldo E Martinez-Outschoorn; Diana Whitaker-Menezes; Anthony Howell; Federica Sotgia; Michael P Lisanti Journal: Antioxid Redox Signal Date: 2011-11-17 Impact factor: 8.401
Authors: C Marín Hernández; A Piñero Madrona; P J Gil Vázquez; P J Galindo Fernández; G Ruiz Merino; J L Alonso Romero; P Parrilla Paricio Journal: Clin Transl Oncol Date: 2017-08-07 Impact factor: 3.405
Authors: Jérôme Galon; Franck Pagès; Francesco M Marincola; Helen K Angell; Magdalena Thurin; Alessandro Lugli; Inti Zlobec; Anne Berger; Carlo Bifulco; Gerardo Botti; Fabiana Tatangelo; Cedrik M Britten; Sebastian Kreiter; Lotfi Chouchane; Paolo Delrio; Hartmann Arndt; Martin Asslaber; Michele Maio; Giuseppe V Masucci; Martin Mihm; Fernando Vidal-Vanaclocha; James P Allison; Sacha Gnjatic; Leif Hakansson; Christoph Huber; Harpreet Singh-Jasuja; Christian Ottensmeier; Heinz Zwierzina; Luigi Laghi; Fabio Grizzi; Pamela S Ohashi; Patricia A Shaw; Blaise A Clarke; Bradly G Wouters; Yutaka Kawakami; Shoichi Hazama; Kiyotaka Okuno; Ena Wang; Jill O'Donnell-Tormey; Christine Lagorce; Graham Pawelec; Michael I Nishimura; Robert Hawkins; Réjean Lapointe; Andreas Lundqvist; Samir N Khleif; Shuji Ogino; Peter Gibbs; Paul Waring; Noriyuki Sato; Toshihiko Torigoe; Kyogo Itoh; Prabhu S Patel; Shilin N Shukla; Richard Palmqvist; Iris D Nagtegaal; Yili Wang; Corrado D'Arrigo; Scott Kopetz; Frank A Sinicrope; Giorgio Trinchieri; Thomas F Gajewski; Paolo A Ascierto; Bernard A Fox Journal: J Transl Med Date: 2012-10-03 Impact factor: 5.531