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Literature DB >> 20838861

Brain proton magnetic spectroscopy in long-term treatment of Wilson's disease patients.

Beata Tarnacka¹, Wojciech Szeszkowski, Marek Gołębiowski, Anna Członkowska.

Abstract

We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson's disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated four hWD patients, with no improvement and eight with marked improvement; and eight nWD patients with marked improvement and seven with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Protons

Year: 2010 PMID： 20838861 DOI： 10.1007/s11011-010-9214-x

Source DB: PubMed Journal: Metab Brain Dis ISSN： 0885-7490 Impact factor: 3.584

16 in total

Review 1. Clinical significance of basal ganglia alterations at brain MRI and 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy.

Authors: Laurent Spahr; Pierre R Burkhard; Hannelore Grötzsch; Antoine Hadengue
Journal: Metab Brain Dis Date: 2002-12 Impact factor: 3.584

2. The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons.

Authors: Marlena Zyśk; Monika Sakowicz-Burkiewicz; Piotr Pikul; Robert Kowalski; Anna Michno; Tadeusz Pawełczyk
Journal: Antioxidants (Basel) Date: 2020-06-13

2 in total

Brain proton magnetic spectroscopy in long-term treatment of Wilson's disease patients.

Review 1. Clinical significance of basal ganglia alterations at brain MRI and 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy.

2. Wilson's disease: cranial MRI observations and clinical correlation.

Review 3. Proton MRS in neurological disorders.

4. Proton MR spectroscopy in Wilson disease: analysis of 36 cases.

5. Initial and follow-up brain MRI findings and correlation with the clinical course in Wilson's disease.

6. Regional variations in cerebral proton spectroscopy in patients with chronic hepatic encephalopathy.

7. Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.

8. MR spectroscopy in monitoring the treatment of Wilson's disease patients.

9. Neuropathological findings in penicillamine-treated patients with Wilson's disease.

10. Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.

Review 1. Bilateral symmetrical basal ganglia and thalamic lesions in children: an update (2015).

2. The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons.