| Literature DB >> 20837078 |
Sarah A Ngugi1, Valeria V Ventura, Omar Qazi, Sarah V Harding, G Barrie Kitto, D Mark Estes, Anne Dell, Richard W Titball, Timothy P Atkins, Katherine A Brown, Paul G Hitchen, Joann L Prior.
Abstract
Burkholderia thailandensis is a less virulent close relative of Burkholderia pseudomallei, a CDC category B biothreat agent. We have previously shown that lipopolysaccharide (LPS) extracted from B. pseudomallei can provide protection against a lethal challenge of B. pseudomallei in a mouse model of melioidosis. Sugar analysis on LPS from B. thailandensis strain E264 confirmed that this polysaccharide has a similar structure to LPS from B. pseudomallei. Mice were immunised with LPS from B. thailandensis or B. pseudomallei and challenged with a lethal dose of B. pseudomallei strain K96243. Similar protection levels were observed when either LPS was used as the immunogen. This data suggests that B. thailandensis LPS has the potential to be used as part of a subunit based vaccine against pathogenic B. pseudomallei. CrownEntities:
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Year: 2010 PMID： 20837078 DOI： 10.1016/j.vaccine.2010.08.058
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641