| Literature DB >> 20836516 |
Jun Deguchi1, Tomokazu Shoji, Alfarius E Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Osamu Shirota, Khalijah Awang, A Hamid A Hadi, Hiroshi Morita.
Abstract
Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20836516 DOI： 10.1021/np100458b
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050