Literature DB >> 20835849

Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses.

Lamjed Bouslama1, Kyoko Hayashi, Jung-Bum Lee, Abdelwahed Ghorbel, Toshimitsu Hayashi.   

Abstract

In this study, we evaluated the inhibitory effect of ethanol and aqueous extracts from a stem of Opuntia ficus indica on replication of three kinds of viruses: two enveloped viruses [herpes simplex virus type 2 (HSV-2), influenza A virus (IFV-A)], and one non-enveloped virus [poliovirus type 1 (PV-1)]. Only ethanol extract from the cactus stem showed significant antiviral activity in vitro. Two chlorophyll derivatives, pheophorbide a and pyropheophorbide a, were isolated as active substances exhibiting potent virucidal effects on HSV-2 and IFV-A, but no activity against PV-1 was observed. These findings suggest that these active compounds might recognize specific glycoproteins of enveloped viruses, precluding their binding to host cell receptors and inhibiting viral infections.

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Year:  2010        PMID： 20835849     DOI： 10.1007/s11418-010-0468-8

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  16 in total

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Authors:  E H Park; J H Kahng; S H Lee; K H Shin
Journal:  Fitoterapia       Date:  2001-03       Impact factor: 2.882

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Journal:  J Nutr       Date:  1990-11       Impact factor: 4.798

3.  Quantitative comparison of techniques used to measure complement-mediated cytotoxicity of nucleated cells.

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Journal:  J Immunol       Date:  1975-01       Impact factor: 5.422

4.  Direct assessment of viral aerosols on cell cultures.

Authors:  W A Hankins; H J Hearn
Journal:  Appl Microbiol       Date:  1970-08

5.  Antioxidant property of an ethanol extract of the stem of Opuntia ficus-indica var. saboten.

Authors:  Jeong-Chae Lee; Hak-Ryul Kim; Ju Kim; Yong-Suk Jang
Journal:  J Agric Food Chem       Date:  2002-10-23       Impact factor: 5.279

6.  High-performance liquid chromatographic screening of chlorophyll derivatives produced during fruit storage.

Authors:  L Almela; J A Fernández-López; M J Roca
Journal:  J Chromatogr A       Date:  2000-02-18       Impact factor: 4.759

7.  Isolation of pyropheophorbide a from the leaves of Atalantia monophylla (ROXB.) CORR. (Rutaceae) as a possible antiviral active principle against herpes simplex virus type 2.

Authors:  S Chansakaow; N Ruangrungsi; T Ishikawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  1996-07       Impact factor: 1.645

8.  A purified extract from prickly pear cactus (Opuntia fuliginosa) controls experimentally induced diabetes in rats.

Authors:  A Trejo-González; G Gabriel-Ortiz; A M Puebla-Pérez; M D Huízar-Contreras; M R Munguía-Mazariegos; S Mejía-Arreguín; E Calva
Journal:  J Ethnopharmacol       Date:  1996-12       Impact factor: 4.360

9.  Analysis of chlorophylls and their derivatives by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

Authors:  Toshiyuki Suzuki; Hitoshi Midonoya; Yuzo Shioi
Journal:  Anal Biochem       Date:  2009-04-11       Impact factor: 3.365

10.  Reduction in plaque size and reduction in plaque number as differing indices of influenza virus-antibody reactions.

Authors:  R I Jahiel; E D Kilbourne
Journal:  J Bacteriol       Date:  1966-11       Impact factor: 3.490
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  6 in total

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Journal:  Afr J Tradit Complement Altern Med       Date:  2012-07-01

3.  Seasonal variation of pheophorbide a and flavonoid in different organs of two Carpinus species and its correlation with immunosuppressive activity.

Authors:  Qianqian Sheng; Xianying Fang; Zunling Zhu; Wei Xiao; Zhenzhong Wang; Gang Ding; Linguo Zhao; Yujian Li; Ping Yu; Zhibin Ding; Qinru Sun
Journal:  In Vitro Cell Dev Biol Anim       Date:  2016-04-25       Impact factor: 2.416

4.  The seafood Musculus senhousei shows anti-influenza A virus activity by targeting virion envelope lipids.

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Journal:  Biochem Pharmacol       Date:  2020-04-17       Impact factor: 5.858

5.  A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses.

Authors:  Thomas Meunier; Lowiese Desmarets; Simon Bordage; Sevser Sahpaz; Karin Séron; Moussa Bamba; Kévin Hervouet; Yves Rouillé; Nathan François; Marion Decossas; Valentin Sencio; François Trottein; Fézan Honora Tra Bi; Olivier Lambert; Jean Dubuisson; Sandrine Belouzard
Journal:  Antimicrob Agents Chemother       Date:  2021-11-22       Impact factor: 5.191

6.  Anti-HIV Activity of Ocimum labiatum Extract and Isolated Pheophytin-a.

Authors:  Petrina Kapewangolo; Martha Kandawa-Schulz; Debra Meyer
Journal:  Molecules       Date:  2017-11-06       Impact factor: 4.411
  6 in total

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