AIMS: Inflammation plays a role in the genesis and perpetuation of atrial fibrillation (AF). Interleukin (IL)-18 is a pleiotropic proinflammatory cytokine with a central role in the inflammatory cascade. We hypothesize that the circulating IL-18 concentration is elevated in AF patients. METHODS AND RESULTS: In a case-control study design, 56 cases with AF and 26 controls were enrolled. All AF cases were categorized into paroxysmal and persistent AF or lone AF and AF with hypertension. Circulating levels of IL-18, tumour necrosis factor-α, high-sensitivity C-reactive protein, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP-1 were measured. In adjusted analyses, only age, MMP-9, and IL-18 were independently associated with AF, in which IL-18 had the most significant association (P = 0.0011, standardized estimate &bgr = 1.76, OR = 1.02, 95% confidence interval: 1.01-1.03). Interleukin-18 levels in persistent AF patients were higher than those in paroxysmal ones (P = 0.0011). Patients who developed AF within 24 h prior to sampling displayed a higher level of IL-18 than those with sinus rhythm (P = 0.0027). Interleukin-18 was positively correlated with left atrial diameter (r = 0.33, P = 0.0117). CONCLUSION: This study documents the elevated IL-18 in AF patients. Interleukin-18 may be superior to other inflammatory markers which are known to be elevated in AF.
AIMS: Inflammation plays a role in the genesis and perpetuation of atrial fibrillation (AF). Interleukin (IL)-18 is a pleiotropic proinflammatory cytokine with a central role in the inflammatory cascade. We hypothesize that the circulating IL-18 concentration is elevated in AFpatients. METHODS AND RESULTS: In a case-control study design, 56 cases with AF and 26 controls were enrolled. All AF cases were categorized into paroxysmal and persistent AF or lone AF and AF with hypertension. Circulating levels of IL-18, tumour necrosis factor-α, high-sensitivity C-reactive protein, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP-1 were measured. In adjusted analyses, only age, MMP-9, and IL-18 were independently associated with AF, in which IL-18 had the most significant association (P = 0.0011, standardized estimate &bgr = 1.76, OR = 1.02, 95% confidence interval: 1.01-1.03). Interleukin-18 levels in persistent AFpatients were higher than those in paroxysmal ones (P = 0.0011). Patients who developed AF within 24 h prior to sampling displayed a higher level of IL-18 than those with sinus rhythm (P = 0.0027). Interleukin-18 was positively correlated with left atrial diameter (r = 0.33, P = 0.0117). CONCLUSION: This study documents the elevated IL-18 in AFpatients. Interleukin-18 may be superior to other inflammatory markers which are known to be elevated in AF.
Authors: Chunxia Yao; Tina Veleva; Larry Scott; Shuyi Cao; Luge Li; Gong Chen; Prince Jeyabal; Xiaolu Pan; Katherina M Alsina; Issam Abu-Taha; Shokoufeh Ghezelbash; Corey L Reynolds; Ying H Shen; Scott A LeMaire; Wilhelm Schmitz; Frank U Müller; Ali El-Armouche; N Tony Eissa; Christine Beeton; Stanley Nattel; Xander H T Wehrens; Dobromir Dobrev; Na Li Journal: Circulation Date: 2018-11-13 Impact factor: 29.690
Authors: Larry Scott; Anke C Fender; Arnela Saljic; Luge Li; Xiaohui Chen; Xiaolei Wang; Dominik Linz; Jilu Lang; Mathias Hohl; Darragh Twomey; Thuy T Pham; Rodrigo Diaz-Lankenau; Mihail G Chelu; Markus Kamler; Mark L Entman; George E Taffet; Prashanthan Sanders; Dobromir Dobrev; Na Li Journal: Cardiovasc Res Date: 2021-06-16 Impact factor: 10.787
Authors: Eddy Wang; Katy Chong; Mei Yu; Noushin Akhoundsadegh; David J Granville; Jerry Shapiro; Kevin J McElwee Journal: PLoS One Date: 2013-04-26 Impact factor: 3.240