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Literature DB >> 30316645

Role of inflammatory signaling in atrial fibrillation.

Abstract

Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced inflammatory response. Emerging evidence points to a causal role of inflammatory signaling pathways in the evolution of atrial electrical, calcium handling and structural remodeling, which create the substrate of AF development. In this review, we discuss the clinical evidence supporting the association between inflammatory indices and AF development, the molecular and cellular mechanisms of AF, which appear to involve multiple canonical inflammatory pathways, and the potential of anti-inflammatory therapeutic approaches in AF prevention/treatment.

Entities: Chemical Disease Gene Species

Keywords: Atrial fibrillation; IL-1β; Inflammasome; Inflammation; NFκB; TNF-α

Mesh：

Substances：

Year: 2018 PMID： 30316645 PMCID： PMC6447485 DOI： 10.1016/j.ijcard.2018.10.020

Source DB: PubMed Journal: Int J Cardiol ISSN： 0167-5273 Impact factor: 4.164

74 in total

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Review 7. Novel molecular targets for atrial fibrillation therapy.

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9. Association of inflammatory factors with occurrence and recurrence of atrial fibrillation: a meta-analysis.

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Journal: Int J Cardiol Date: 2013-09-08 Impact factor: 4.164

Review 10. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes.

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23 in total

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Review 7. Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it.

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Review 9. Novel Combined Antioxidant Strategy against Hypertension, Acute Myocardial Infarction and Postoperative Atrial Fibrillation.

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Review 10. Exosomes in atrial fibrillation: therapeutic potential and role as clinical biomarkers.

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Journal: Heart Fail Rev Date: 2021-07-12 Impact factor: 4.654