Literature DB >> 20827226

EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target.

Ari J Kane1, Michael E Sughrue, Martin J Rutkowski, Joanna J Phillips, Andrew T Parsa.   

Abstract

Epidermal growth factor module-containing mucin-like hormone receptor-3 (EMR-3) is a G-protein coupled receptor with unknown ligand and cellular function. Upregulation of EMR-3 in glioblastoma (GBM) multiforme is associated with poor survival. We investigated the expression patterns and functional significance of EMR-3 in GBM using immunohistochemistry, western blot, reverse transcription PCR, and small interfering RNA knockdown in proliferation and invasion assays. EMR-3 is variably expressed in primary human GBM tissues and cell lines. Knocking down EMR-3 has no impact on cellular proliferation, but decreases cellular invasion by greater than 3-fold. EMR-3 is a potential mediator of cellular invasion in GBM. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, our results provide impetus to explore EMR-3 as a potential therapeutic target.

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Year:  2010        PMID： 20827226      PMCID： PMC3064464          DOI： 10.1097/WNR.0b013e32833f19f2

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  10 in total

1.  Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils.

Authors:  M Stacey; H H Lin; K L Hilyard; S Gordon; A J McKnight
Journal:  J Biol Chem       Date:  2001-03-14       Impact factor: 5.157

2.  The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.

Authors:  Mourad Matmati; Walter Pouwels; Robin van Bruggen; Machiel Jansen; Robert M Hoek; Arthur J Verhoeven; Jörg Hamann
Journal:  J Leukoc Biol       Date:  2006-11-15       Impact factor: 4.962

Review 3.  Adhesion-GPCRs: emerging roles for novel receptors.

Authors:  Simon Yona; Hsi-Hsien Lin; Willie O Siu; Siamon Gordon; Martin Stacey
Journal:  Trends Biochem Sci       Date:  2008-09-11       Impact factor: 13.807

4.  Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas.

Authors:  Tarek Mustafa; Alexander Eckert; Thomas Klonisch; Astrid Kehlen; Peter Maurer; Michael Klintschar; Mabruk Erhuma; Robby Zschoyan; Oliver Gimm; Henning Dralle; Johannes Schubert; Cuong Hoang-Vu
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2005-01       Impact factor: 4.254

5.  A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival.

Authors:  M Lacroix; D Abi-Said; D R Fourney; Z L Gokaslan; W Shi; F DeMonte; F F Lang; I E McCutcheon; S J Hassenbusch; E Holland; K Hess; C Michael; D Miller; R Sawaya
Journal:  J Neurosurg       Date:  2001-08       Impact factor: 5.115

6.  Human glioma demonstrates cell line specific results with ATP-based chemiluminescent cellular proliferation assays.

Authors:  Michael E Sughrue; Martin J Rutkowski; Ari J Kane; Andrew T Parsa
Journal:  J Clin Neurosci       Date:  2010-09-09       Impact factor: 1.961

7.  Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults.

Authors:  Andrew T Parsa; Scott Wachhorst; Kathleen R Lamborn; Michael D Prados; Michael W McDermott; Mitchel S Berger; Susan M Chang
Journal:  J Neurosurg       Date:  2005-04       Impact factor: 5.115

8.  Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function.

Authors:  Simon Yona; Hsi-Hsien Lin; Pietro Dri; John Q Davies; Richard P G Hayhoe; Sion M Lewis; Sigrid E M Heinsbroek; K Alun Brown; Mauro Perretti; Jörg Hamann; David F Treacher; Siamon Gordon; Martin Stacey
Journal:  FASEB J       Date:  2007-10-10       Impact factor: 5.191

9.  The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.

Authors:  Martin Stacey; Gin-Wen Chang; John Q Davies; Mark J Kwakkenbos; Ralph D Sanderson; Jörg Hamann; Siamon Gordon; Hsi-Hsien Lin
Journal:  Blood       Date:  2003-06-26       Impact factor: 22.113

10.  CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells.

Authors:  Gin-Wen Chang; John Q Davies; Martin Stacey; Simon Yona; Dawn M E Bowdish; Jörg Hamann; Tse-Ching Chen; Chun-Yen Lin; Siamon Gordon; Hsi-Hsien Lin
Journal:  Biochem Biophys Res Commun       Date:  2006-12-12       Impact factor: 3.575
  10 in total
  12 in total

Review 1.  The Emerging Role of Adhesion GPCRs in Cancer.

Authors:  Abanoub A Gad; Nariman Balenga
Journal:  ACS Pharmacol Transl Sci       Date:  2020-01-13

Review 2.  Adhesion GPCRs in Tumorigenesis.

Authors:  Gabriela Aust; Dan Zhu; Erwin G Van Meir; Lei Xu
Journal:  Handb Exp Pharmacol       Date:  2016

Review 3.  The association of long non-coding RNA in the prognosis of oral squamous cell carcinoma.

Authors:  Agnik Haldar; Ajay Kumar Singh
Journal:  Genes Genomics       Date:  2022-01-13       Impact factor: 1.839

4.  [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].

Authors:  X Zhou; S Lei; L Li; T Xu; W Gu; F Ma; R Yang
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2021-10-20

5.  Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas.

Authors:  Michael E Ivan; Michael Safaee; Taemin Oh; Aaron J Clark; Matthew Z Sun; Joseph Kim; Orin Bloch; Arman Jahangiri; Joanna J Phillips; Manish K Aghi; Andrew T Parsa
Journal:  J Neurooncol       Date:  2014-09-09       Impact factor: 4.130

Review 6.  Systematic review of protein biomarkers of invasive behavior in glioblastoma.

Authors:  Eli T Sayegh; Gurvinder Kaur; Orin Bloch; Andrew T Parsa
Journal:  Mol Neurobiol       Date:  2013-11-24       Impact factor: 5.590

7.  Genomic alterations in breast cancer patients in betel quid and non betel quid chewers.

Authors:  Mishi Kaushal; Ashwani K Mishra; Jagannath Sharma; Eric Zomawia; Amal Kataki; Sujala Kapur; Sunita Saxena
Journal:  PLoS One       Date:  2012-08-24       Impact factor: 3.240

8.  Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients.

Authors:  Michael Safaee; Aaron J Clark; Michael C Oh; Michael E Ivan; Orin Bloch; Gurvinder Kaur; Matthew Z Sun; Joseph M Kim; Taemin Oh; Mitchel S Berger; Andrew T Parsa
Journal:  PLoS One       Date:  2013-04-26       Impact factor: 3.240

Review 9.  The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers.

Authors:  Michael Safaee; Michael E Ivan; Michael C Oh; Taemin Oh; Eli T Sayegh; Gurvinder Kaur; Matthew Z Sun; Orin Bloch; Andrew T Parsa
Journal:  Oncol Rev       Date:  2014-04-01

10.  Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility.

Authors:  Richarda M de Voer; Marc-Manuel Hahn; Robbert D A Weren; Arjen R Mensenkamp; Christian Gilissen; Wendy A van Zelst-Stams; Liesbeth Spruijt; C Marleen Kets; Junxiao Zhang; Hanka Venselaar; Lilian Vreede; Nil Schubert; Marloes Tychon; Ronny Derks; Hans K Schackert; Ad Geurts van Kessel; Nicoline Hoogerbrugge; Marjolijn J L Ligtenberg; Roland P Kuiper
Journal:  PLoS Genet       Date:  2016-02-22       Impact factor: 5.917
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