Literature DB >> 20825283

Genetic engineering of mesenchymal stem cells and its application in human disease therapy.

Conrad P Hodgkinson1, José A Gomez, Maria Mirotsou, Victor J Dzau.   

Abstract

The use of stem cells for tissue regeneration and repair is advancing both at the bench and bedside. Stem cells isolated from bone marrow are currently being tested for their therapeutic potential in a variety of clinical conditions including cardiovascular injury, kidney failure, cancer, and neurological and bone disorders. Despite the advantages, stem cell therapy is still limited by low survival, engraftment, and homing to damage area as well as inefficiencies in differentiating into fully functional tissues. Genetic engineering of mesenchymal stem cells is being explored as a means to circumvent some of these problems. This review presents the current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction. Advancements in other disease areas are also discussed.

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Year:  2010        PMID： 20825283      PMCID： PMC2978545          DOI： 10.1089/hum.2010.165

Source DB:  PubMed          Journal:  Hum Gene Ther        ISSN： 1043-0342            Impact factor:   5.695


  190 in total

Review 1.  Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration.

Authors:  Jyoti A Kode; Shayanti Mukherjee; Mugdha V Joglekar; Anandwardhan A Hardikar
Journal:  Cytotherapy       Date:  2009       Impact factor: 5.414

2.  Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.

Authors:  Koen E A van der Bogt; Sonja Schrepfer; Jin Yu; Ahmad Y Sheikh; Grant Hoyt; Johannes A Govaert; Jeffrey B Velotta; Christopher H Contag; Robert C Robbins; Joseph C Wu
Journal:  Transplantation       Date:  2009-03-15       Impact factor: 4.939

3.  Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression.

Authors:  Yao Liang Tang; Wuqiang Zhu; Min Cheng; Lijuan Chen; John Zhang; Tao Sun; Raj Kishore; M Ian Phillips; Douglas W Losordo; Gangjian Qin
Journal:  Circ Res       Date:  2009-04-30       Impact factor: 17.367

4.  Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction.

Authors:  Marc-Michael Zaruba; Hans Diogenes Theiss; Markus Vallaster; Ursula Mehl; Stefan Brunner; Robert David; Rebekka Fischer; Lisa Krieg; Eva Hirsch; Bruno Huber; Petra Nathan; Lars Israel; Axel Imhof; Nadja Herbach; Gerald Assmann; Ruediger Wanke; Josef Mueller-Hoecker; Gerhard Steinbeck; Wolfgang-Michael Franz
Journal:  Cell Stem Cell       Date:  2009-04-03       Impact factor: 24.633

5.  Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans.

Authors:  Lingyun Sun; Kentaro Akiyama; Huayong Zhang; Takayoshi Yamaza; Yayi Hou; Shengnan Zhao; Ting Xu; Anh Le; Songtao Shi
Journal:  Stem Cells       Date:  2009-06       Impact factor: 6.277

6.  Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer.

Authors:  Michael R Loebinger; Ayad Eddaoudi; Derek Davies; Sam M Janes
Journal:  Cancer Res       Date:  2009-05-12       Impact factor: 12.701

7.  Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats.

Authors:  Gang Xu; Xiao-Dan Jiang; Ying Xu; Jing Zhang; Fan-Heng Huang; Zhen-Zhou Chen; De-Xiang Zhou; Jiang-Hua Shang; Yu-Xi Zou; Ying-Qian Cai; Sheng-Bin Kou; Yi-Zhao Chen; Ru-Xiang Xu; Yan-Jun Zeng
Journal:  Cell Biol Int       Date:  2008-08-06       Impact factor: 3.612

8.  Importance of the SDF-1:CXCR4 axis in myocardial repair.

Authors:  Marc S Penn
Journal:  Circ Res       Date:  2009-05-22       Impact factor: 17.367

9.  Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury.

Authors:  Kaliyamurthi Venkatachalam; Sumanth D Prabhu; Venkatapuram Seenu Reddy; William H Boylston; Anthony J Valente; Bysani Chandrasekar
Journal:  J Biol Chem       Date:  2009-01-21       Impact factor: 5.157

10.  Effect of cardiac rehabilitation on angiogenic cytokines in postinfarction patients.

Authors:  B-C Lee; H-C Hsu; W-Y I Tseng; M-Y M Su; S-Y Chen; Y-W Wu; K-L Chien; M-F Chen
Journal:  Heart       Date:  2009-03-19       Impact factor: 5.994
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  59 in total

1.  Fetal liver-derived mesenchymal stem cell engraftment after allogeneic in utero transplantation into rabbits.

Authors:  Rafael Moreno; Itziar Martínez-González; Marta Rosal; Marga Nadal; Jordi Petriz; Eduard Gratacós; Josep M Aran
Journal:  Stem Cells Dev       Date:  2011-06-01       Impact factor: 3.272

Review 2.  Mesenchymal stem cell-based tumor-targeted gene therapy in gastrointestinal cancer.

Authors:  Qi Bao; Yue Zhao; Hanno Niess; Claudius Conrad; Bettina Schwarz; Karl-Walter Jauch; Ralf Huss; Peter J Nelson; Christiane J Bruns
Journal:  Stem Cells Dev       Date:  2012-06-26       Impact factor: 3.272

Review 3.  Role of mesenchymal stem cells in leukaemia: Dr. Jekyll or Mr. Hyde?

Authors:  Rebecca S Y Wong; Soon-Keng Cheong
Journal:  Clin Exp Med       Date:  2013-06-23       Impact factor: 3.984

4.  Mimicking the inflammatory cell adhesion cascade by nucleic acid aptamer programmed cell-cell interactions.

Authors:  Weian Zhao; Weili Loh; Ilia A Droujinine; Weisuong Teo; Namit Kumar; Sebastian Schafer; Cheryl H Cui; Liang Zhang; Debanjan Sarkar; Rohit Karnik; Jeffrey M Karp
Journal:  FASEB J       Date:  2011-06-07       Impact factor: 5.191

5.  Stem cells and cell therapies in lung biology and lung diseases.

Authors:  Daniel J Weiss; Ivan Bertoncello; Zea Borok; Carla Kim; Angela Panoskaltsis-Mortari; Susan Reynolds; Mauricio Rojas; Barry Stripp; David Warburton; Darwin J Prockop
Journal:  Proc Am Thorac Soc       Date:  2011-06

Review 6.  Engineered Mesenchymal Stem Cells for Targeting Solid Tumors: Therapeutic Potential beyond Regenerative Therapy.

Authors:  Shen Cheng; Susheel Kumar Nethi; Sneha Rathi; Buddhadev Layek; Swayam Prabha
Journal:  J Pharmacol Exp Ther       Date:  2019-06-07       Impact factor: 4.030

Review 7.  In vitro augmentation of mesenchymal stem cells viability in stressful microenvironments : In vitro augmentation of mesenchymal stem cells viability.

Authors:  Fatemeh Amiri; Ali Jahanian-Najafabadi; Mehryar Habibi Roudkenar
Journal:  Cell Stress Chaperones       Date:  2014-12-20       Impact factor: 3.667

8.  Lentivirus transduction of human osteoclast precursor cells and differentiation into functional osteoclasts.

Authors:  Margaret L Ramnaraine; Wendy E Mathews; Denis R Clohisy
Journal:  Bone       Date:  2011-10-01       Impact factor: 4.398

Review 9.  Mesenchymal Stem Cell Therapy for Cutaneous Wounds.

Authors:  Anne M Hocking
Journal:  Adv Wound Care (New Rochelle)       Date:  2012-08       Impact factor: 4.730

10.  Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation.

Authors:  Ning Wu; Yu-Ling Zhang; Hai-Tian Wang; Da-Wei Li; Hui-Juan Dai; Qi-Qi Zhang; Jiang Zhang; Yong Ma; Qiang Xia; Jian-Min Bian; Hua-Lian Hang
Journal:  Cancer Biol Ther       Date:  2016-05-03       Impact factor: 4.742
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