OBJECTIVE: To determine whether cardiac rehabilitation influences plasma levels of angiogenic cytokines and their correlation with myocardial blood flow (MBF). DESIGN: Randomised controlled study. SETTING: Tertiary cardiac centre. PATIENTS: 39 postinfarction patients randomised to either a 3-month training group (n = 20) or a non-training group (n = 19), and 19 normal controls. INTERVENTIONS:Cardiac rehabilitation. MAIN OUTCOME MEASURES: MBF by cardiac magnetic resonance imaging, and plasma levels of stem cell factor (SCF), stromal-derived factor-1 (SDF-1), and vascular endothelial growth factor (VEGF) measured at enrolment and at 3 months after randomisation. RESULTS: At baseline, when compared with the healthy subjects, postinfarction patients had a lower MBF in the infarcted myocardium during dipyridamole-induced stress (1.65 (0.58) vs 2.77 (0.78) ml/min/g, p<0.001) but higher plasma levels of VEGF (3.65 (0.75) vs 2.77 (0.59) pg/ml, p<0.001 expressed as the natural logarithm) and SDF-1 (2113 (345) vs 1869 (309) pg/ml, p = 0.009). Only SDF-1 was inversely associated with stress MBF in both remote (r = -0.39, p = 0.03) and infarcted myocardium (r = -0.62, p<0.001). After 3 months, the training group's stress MBF had increased by 33% in the remote (p<0.001) and 28% in infarcted myocardium (p = 0.02), while VEGF decreased by 9% (p = 0.01), and SDF-1 decreased by 11% (p = 0.02). The change in SDF-1 was inversely correlated with the change in stress MBF in both remote (r = -0.40, p = 0.01) and infarcted myocardium (r = -0.50, p = 0.001). In the non-training group, MBF and cytokines were unchanged. CONCLUSION:Cardiac rehabilitation improves stress MBF in postinfarction patients, with an inverse decrease in circulating angiogenic cytokines.
RCT Entities:
OBJECTIVE: To determine whether cardiac rehabilitation influences plasma levels of angiogenic cytokines and their correlation with myocardial blood flow (MBF). DESIGN: Randomised controlled study. SETTING: Tertiary cardiac centre. PATIENTS: 39 postinfarction patients randomised to either a 3-month training group (n = 20) or a non-training group (n = 19), and 19 normal controls. INTERVENTIONS: Cardiac rehabilitation. MAIN OUTCOME MEASURES: MBF by cardiac magnetic resonance imaging, and plasma levels of stem cell factor (SCF), stromal-derived factor-1 (SDF-1), and vascular endothelial growth factor (VEGF) measured at enrolment and at 3 months after randomisation. RESULTS: At baseline, when compared with the healthy subjects, postinfarction patients had a lower MBF in the infarcted myocardium during dipyridamole-induced stress (1.65 (0.58) vs 2.77 (0.78) ml/min/g, p<0.001) but higher plasma levels of VEGF (3.65 (0.75) vs 2.77 (0.59) pg/ml, p<0.001 expressed as the natural logarithm) and SDF-1 (2113 (345) vs 1869 (309) pg/ml, p = 0.009). Only SDF-1 was inversely associated with stress MBF in both remote (r = -0.39, p = 0.03) and infarcted myocardium (r = -0.62, p<0.001). After 3 months, the training group's stress MBF had increased by 33% in the remote (p<0.001) and 28% in infarcted myocardium (p = 0.02), while VEGF decreased by 9% (p = 0.01), and SDF-1 decreased by 11% (p = 0.02). The change in SDF-1 was inversely correlated with the change in stress MBF in both remote (r = -0.40, p = 0.01) and infarcted myocardium (r = -0.50, p = 0.001). In the non-training group, MBF and cytokines were unchanged. CONCLUSION: Cardiac rehabilitation improves stress MBF in postinfarction patients, with an inverse decrease in circulating angiogenic cytokines.
Authors: Andrew J Boyle; Yerem Yeghiazarians; Henry Shih; Joy Hwang; Jianqin Ye; Rich Sievers; Daiwei Zheng; Jath Palasubramaniam; Dharshan Palasubramaniam; Connie Karschimkus; Robert Whitbourn; Alicia Jenkins; Andrew M Wilson Journal: J Transl Med Date: 2011-09-12 Impact factor: 5.531
Authors: Muhammad Hammadah; Ayman Samman Tahhan; Ibhar Al Mheid; Kobina Wilmot; Ronnie Ramadan; Bryan R Kindya; Heval M Kelli; Wesley T O'Neal; Pratik Sandesara; Samaah Sullivan; Zakaria Almuwaqqat; Malik Obideen; Naser Abdelhadi; Ayman Alkhoder; Pratik M Pimple; Oleksiy Levantsevych; Kareem H Mohammed; Lei Weng; Laurence S Sperling; Amit J Shah; Yan V Sun; Brad D Pearce; Michael Kutner; Laura Ward; J Douglas Bremner; Jinhee Kim; Edmund K Waller; Paolo Raggi; David Sheps; Viola Vaccarino; Arshed A Quyyumi Journal: J Am Heart Assoc Date: 2018-02-10 Impact factor: 5.501
Authors: Alessandra Borlotti; Michael Jerosch-Herold; Dan Liu; Dafne Viliani; Alessia Bracco; Mohammad Alkhalil; Giovanni Luigi De Maria; Keith M Channon; Adrian P Banning; Robin P Choudhury; Stefan Neubauer; Rajesh K Kharbanda; Erica Dall'Armellina Journal: JACC Cardiovasc Imaging Date: 2019-01-16