BACKGROUND: Valid, sustained and safe clinical means of colorectal cancer prevention are still lacking, but they are urgently needed to lower the incidence of colorectal cancer. Dietary factors and phytochemicals such as flavonoids play an important role for prevention. METHODS: A selective search of the literature using PubMed was performed with the following key words: flavonoids, cancer, therapy, colorectal cancer focused on clinical queries. Results of clinical studies including the authors' own were compared. RESULTS: In vivo and in vitro studies with animals, cell cultures and subcellular components provide ample evidence for antimutagenic and anticarcinogenic effects of flavonoids as shown for multiple biological and molecular endpoints. Isoflavonoids in vitro have been shown to induce proliferation of breast cancer cells. Epidemiologic trials (cohort, case-control and cross-sectional studies) yielded inconsistent results for flavonoid protection. Systematic reviews and meta-analyses support the protective role of tea flavonoids on adenoma incidence. An interventional pilot study with sustained flavonoid supplementation was shown to reduce the rate of neoplasia in patients with resected colorectal cancer. CONCLUSION: Selected flavonoids possess antimutagenic and anticarcinogenic properties and could reduce the incidence of colorectal neoplasias as shown in epidemiologic trials. Randomized controlled clinical studies with flavonoid intervention are necessary to provide evidence for their role in colorectal cancer prevention.
BACKGROUND: Valid, sustained and safe clinical means of colorectal cancer prevention are still lacking, but they are urgently needed to lower the incidence of colorectal cancer. Dietary factors and phytochemicals such as flavonoids play an important role for prevention. METHODS: A selective search of the literature using PubMed was performed with the following key words: flavonoids, cancer, therapy, colorectal cancer focused on clinical queries. Results of clinical studies including the authors' own were compared. RESULTS: In vivo and in vitro studies with animals, cell cultures and subcellular components provide ample evidence for antimutagenic and anticarcinogenic effects of flavonoids as shown for multiple biological and molecular endpoints. Isoflavonoids in vitro have been shown to induce proliferation of breast cancer cells. Epidemiologic trials (cohort, case-control and cross-sectional studies) yielded inconsistent results for flavonoid protection. Systematic reviews and meta-analyses support the protective role of tea flavonoids on adenoma incidence. An interventional pilot study with sustained flavonoid supplementation was shown to reduce the rate of neoplasia in patients with resected colorectal cancer. CONCLUSION: Selected flavonoids possess antimutagenic and anticarcinogenic properties and could reduce the incidence of colorectal neoplasias as shown in epidemiologic trials. Randomized controlled clinical studies with flavonoid intervention are necessary to provide evidence for their role in colorectal cancer prevention.
Authors: Jennifer Lin; Shumin M Zhang; Kana Wu; Walter C Willett; Charles S Fuchs; Edward Giovannucci Journal: Am J Epidemiol Date: 2006-08-21 Impact factor: 4.897
Authors: Fränzel J B van Duijnhoven; H Bas Bueno-De-Mesquita; Pietro Ferrari; Mazda Jenab; Hendriek C Boshuizen; Martine M Ros; Corinne Casagrande; Anne Tjønneland; Anja Olsen; Kim Overvad; Ole Thorlacius-Ussing; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Sophie Morois; Rudolf Kaaks; Jakob Linseisen; Heiner Boeing; Ute Nöthlings; Antonia Trichopoulou; Dimitrios Trichopoulos; Gesthimani Misirli; Domenico Palli; Sabina Sieri; Salvatore Panico; Rosario Tumino; Paolo Vineis; Petra Hm Peeters; Carla H van Gils; Marga C Ocké; Eiliv Lund; Dagrun Engeset; Guri Skeie; Laudina Rodríguez Suárez; Carlos A González; María-José Sánchez; Miren Dorronsoro; Carmen Navarro; Aurelio Barricarte; Göran Berglund; Jonas Manjer; Göran Hallmans; Richard Palmqvist; Sheila A Bingham; Kay-Tee Khaw; Timothy J Key; Naomi E Allen; Paolo Boffetta; Nadia Slimani; Sabina Rinaldi; Valentina Gallo; Teresa Norat; Elio Riboli Journal: Am J Clin Nutr Date: 2009-04-01 Impact factor: 7.045
Authors: K Radulovic; S Normand; A Rehman; A Delanoye-Crespin; J Chatagnon; M Delacre; N Waldschmitt; L F Poulin; J Iovanna; B Ryffel; P Rosenstiel; M Chamaillard Journal: Mucosal Immunol Date: 2017-11-15 Impact factor: 7.313