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Literature DB >> 20824264

Role of mitofusin 2 in cardiovascular oxidative injury.

Abstract

Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential, and mtDNA stability. Dysfunction of mitochondrial dynamics has been implicated in various human diseases, especially in neurodegenerative diseases. Emerging evidence indicates that impaired expression of mitochondrial fusion proteins or their malfunction participates in oxidative stress-induced cardiovascular injury. This review will focus on recent advances of mitochondrial fusion in regulating various cellular processes in cardiovascular system.

Entities: Disease Gene Species

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Year: 2010 PMID： 20824264 DOI： 10.1007/s00109-010-0675-5

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

35 in total

1. Unravelling Ras signals in cardiovascular disease.

Authors: Kenneth R Chien; Masahiko Hoshijima
Journal: Nat Cell Biol Date: 2004-09 Impact factor: 28.824

2. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A.

Authors: Stephan Züchner; Irina V Mersiyanova; Maria Muglia; Nisrine Bissar-Tadmouri; Julie Rochelle; Elena L Dadali; Mario Zappia; Eva Nelis; Alessandra Patitucci; Jan Senderek; Yesim Parman; Oleg Evgrafov; Peter De Jonghe; Yuji Takahashi; Shoij Tsuji; Margaret A Pericak-Vance; Aldo Quattrone; Esra Battaloglu; Alexander V Polyakov; Vincent Timmerman; J Michael Schröder; Jeffery M Vance; Esra Battologlu
Journal: Nat Genet Date: 2004-04-04 Impact factor: 38.330

3. Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.

Authors: Daniel Bach; Deborah Naon; Sara Pich; Francesc X Soriano; Nathalie Vega; Jennifer Rieusset; Martine Laville; Christelle Guillet; Yves Boirie; Harriet Wallberg-Henriksson; Melania Manco; Menotti Calvani; Marco Castagneto; Manuel Palacín; Geltrude Mingrone; Juleen R Zierath; Hubert Vidal; Antonio Zorzano
Journal: Diabetes Date: 2005-09 Impact factor: 9.461

4. Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization.

Authors: Margaret Neuspiel; Rodolfo Zunino; Sandhya Gangaraju; Peter Rippstein; Heidi McBride
Journal: J Biol Chem Date: 2005-05-04 Impact factor: 5.157

5. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.

Authors: Valentina Parra; Veronica Eisner; Mario Chiong; Alfredo Criollo; Francisco Moraga; Alejandra Garcia; Steffen Härtel; Enrique Jaimovich; Antonio Zorzano; Cecilia Hidalgo; Sergio Lavandero
Journal: Cardiovasc Res Date: 2007-10-04 Impact factor: 10.787

6. Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras.

Authors: Olga Martins de Brito; Luca Scorrano
Journal: Mitochondrion Date: 2009-03-06 Impact factor: 4.160

7. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.

Authors: Ansgar Santel; Stephan Frank; Brigitte Gaume; Michael Herrler; Richard J Youle; Margaret T Fuller
Journal: J Cell Sci Date: 2003-05-20 Impact factor: 5.285

8. Mitofusin 2 builds a bridge between ER and mitochondria.

Authors: Carsten Merkwirth; Thomas Langer
Journal: Cell Date: 2008-12-26 Impact factor: 41.582

9. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology.

Authors: Tianzheng Yu; James L Robotham; Yisang Yoon
Journal: Proc Natl Acad Sci U S A Date: 2006-02-13 Impact factor: 11.205

10. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.

Authors: Hsiuchen Chen; Marc Vermulst; Yun E Wang; Anne Chomyn; Tomas A Prolla; J Michael McCaffery; David C Chan
Journal: Cell Date: 2010-04-16 Impact factor: 41.582

8 in total

1. Diabetic retinopathy and damage to mitochondrial structure and transport machinery.

Authors: Qing Zhong; Renu A Kowluru
Journal: Invest Ophthalmol Vis Sci Date: 2011-11-07 Impact factor: 4.799

2. Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes.

Authors: Ting Zhao; Xiaohu Huang; Liang Han; Xianhua Wang; Hongqiang Cheng; Yungang Zhao; Quan Chen; Ju Chen; Heping Cheng; Ruiping Xiao; Ming Zheng
Journal: J Biol Chem Date: 2012-05-22 Impact factor: 5.157

Review 3. Mitochondria, myocardial remodeling, and cardiovascular disease.

Authors: Hugo E Verdejo; Andrea del Campo; Rodrigo Troncoso; Tomás Gutierrez; Barbra Toro; Clara Quiroga; Zully Pedrozo; Juan Pablo Munoz; Lorena Garcia; Pablo F Castro; Sergio Lavandero
Journal: Curr Hypertens Rep Date: 2012-12 Impact factor: 5.369

Review 4. Mitophagy in Human Diseases.

Authors: Laura Doblado; Claudia Lueck; Claudia Rey; Alejandro K Samhan-Arias; Ignacio Prieto; Alessandra Stacchiotti; Maria Monsalve
Journal: Int J Mol Sci Date: 2021-04-09 Impact factor: 5.923