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Literature DB >> 19109886

Mitofusin 2 builds a bridge between ER and mitochondria.

Abstract

Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 19109886 DOI： 10.1016/j.cell.2008.12.005

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

51 in total

1. Mitofusin function is dependent on the distinct tissue and organ specific roles of mitochondria.

Authors: Michael N Sack
Journal: J Mol Cell Cardiol Date: 2011-09-12 Impact factor: 5.000

Review 2. Role of mitofusin 2 in cardiovascular oxidative injury.

Authors: Ming Zheng; Rui-Ping Xiao
Journal: J Mol Med (Berl) Date: 2010-09-08 Impact factor: 4.599

Review 3. Wallerian degeneration, wld(s), and nmnat.

Authors: Michael P Coleman; Marc R Freeman
Journal: Annu Rev Neurosci Date: 2010 Impact factor: 12.449

4. Muscle activity prevents the uncoupling of mitochondria from Ca²⁺ Release Units induced by ageing and disuse.

Authors: Laura Pietrangelo; Antonio Michelucci; Patrizia Ambrogini; Stefano Sartini; Flavia A Guarnier; Aurora Fusella; Ilaria Zamparo; Cristina Mammucari; Feliciano Protasi; Simona Boncompagni
Journal: Arch Biochem Biophys Date: 2018-12-20 Impact factor: 4.013

5. Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2.

Authors: Andrea R Conlan; Herbert L Axelrod; Aina E Cohen; Edward C Abresch; John Zuris; David Yee; Rachel Nechushtai; Patricia A Jennings; Mark L Paddock
Journal: J Mol Biol Date: 2009-07-04 Impact factor: 5.469

Review 6. Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease.

Authors: Janet M Shaw; Dennis R Winge
Journal: EMBO Rep Date: 2009-11-13 Impact factor: 8.807

Mitofusin 2 builds a bridge between ER and mitochondria.

1. Mitofusin function is dependent on the distinct tissue and organ specific roles of mitochondria.

Review 2. Role of mitofusin 2 in cardiovascular oxidative injury.

Review 3. Wallerian degeneration, wld(s), and nmnat.

4. Muscle activity prevents the uncoupling of mitochondria from Ca²⁺ Release Units induced by ageing and disuse.

5. Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2.

Review 6. Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease.

7. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function.

Review 8. Potential therapeutic benefits of strategies directed to mitochondria.

9. Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle.

Review 10. Trafficking of heme and porphyrins in metazoa.

Mitofusin 2 builds a bridge between ER and mitochondria.

1. Mitofusin function is dependent on the distinct tissue and organ specific roles of mitochondria.

Review 2. Role of mitofusin 2 in cardiovascular oxidative injury.

Review 3. Wallerian degeneration, wld(s), and nmnat.

4. Muscle activity prevents the uncoupling of mitochondria from Ca2+ Release Units induced by ageing and disuse.

5. Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2.

Review 6. Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease.

7. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function.

Review 8. Potential therapeutic benefits of strategies directed to mitochondria.

9. Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle.

Review 10. Trafficking of heme and porphyrins in metazoa.

4. Muscle activity prevents the uncoupling of mitochondria from Ca²⁺ Release Units induced by ageing and disuse.