Literature DB >> 20822904

3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity.

Kung Ban1, Sandra Duffy, Yelena Khakham, Vicky M Avery, Andrew Hughes, Oliver Montagnat, Kasiram Katneni, Eileen Ryan, Jonathan B Baell.   

Abstract

We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20822904     DOI： 10.1016/j.bmcl.2010.08.065

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

Authors:  Alexander M Jacobine; Jennifer R Mazzone; Rachel D Slack; Abhai K Tripathi; David J Sullivan; Gary H Posner
Journal:  J Med Chem       Date:  2012-08-27       Impact factor: 7.446

2.  The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite.

Authors:  Katherine M Ellis; Leonardo Lucantoni; Marina Chavchich; Matthew Abraham; Amanda De Paoli; Madeline R Luth; Anne-Marie Zeeman; Michael J Delves; Fernando Sánchez-Román Terán; Ursula Straschil; Jake Baum; Clemens H M Kocken; Stuart A Ralph; Elizabeth A Winzeler; Vicky M Avery; Michael D Edstein; Jonathan B Baell; Darren J Creek
Journal:  Antimicrob Agents Chemother       Date:  2021-08-30       Impact factor: 5.191

3.  2-[(Cyclo-hex-3-en-1-ylmeth-oxy)meth-yl]-6-phenyl-1,2,4-triazine-3,5(2H,4H)-dione.

Authors:  Nasser R El-Brollosy; Mohamed I Attia; Ali A El-Emam; Seik Weng Ng; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-19

4.  Novel chalcone derivatives containing a 1,2,4-triazine moiety: design, synthesis, antibacterial and antiviral activities.

Authors:  Xu Tang; Shijun Su; Mei Chen; Jun He; Rongjiao Xia; Tao Guo; Ying Chen; Cheng Zhang; Jun Wang; Wei Xue
Journal:  RSC Adv       Date:  2019-02-19       Impact factor: 4.036

5.  Spectroscopic Behavior and Photophysical Parameters of 2-(Acetoxymethyl)-6-(1,2,4-triazinylaminodihydroquinazolinyl)tetrahydropyran Derivative in Different Solid Hosts.

Authors:  Mahmoud E M Sakr; Maram T H Abou Kana; Ahmed H M Elwahy; Mohamed S Abdelwahed; Samy A El-Daly; El-Zeiny M Ebeid
Journal:  J Fluoresc       Date:  2022-05-06       Impact factor: 2.525
  5 in total

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