Literature DB >> 20822172

An asymmetric hydrogenation route to (-)-spongidepsin.

Ye Zhu1, Aurore Loudet, Kevin Burgess.   

Abstract

(-)-Spongidepsin 1, a cytotoxic marine natural product, was prepared via two iridium-catalyzed hydrogenation reactions; both were highly stereoselective, giving convenient access to pivotal intermediates. This synthesis was modified to give several spongidepsin analogues, and their cytotoxicities were compared with those of the natural product.

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Year:  2010        PMID： 20822172     DOI： 10.1021/ol1018773

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Asymmetric Synthesis of Deoxypropionate Derivatives via Catalytic Hydrogenolysis of Enantioenriched Z-Ketene Heterodimers.

Authors:  Shi Chen; Ahmad A Ibrahim; Mukulesh Mondal; Anthony J Magee; Adam J Cruz; Kraig A Wheeler; Nessan J Kerrigan
Journal:  Org Lett       Date:  2015-06-23       Impact factor: 6.005

2.  Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis.

Authors:  Patrick D Parker; Xintong Hou; Vy M Dong
Journal:  J Am Chem Soc       Date:  2021-04-23       Impact factor: 16.383

Review 3.  Recent Advances in Catalysis Involving Bidentate N-Heterocyclic Carbene Ligands.

Authors:  Abdollah Neshat; Piero Mastrorilli; Ali Mousavizadeh Mobarakeh
Journal:  Molecules       Date:  2021-12-24       Impact factor: 4.411

4.  Asymmetric Baeyer-Villiger oxidation: classical and parallel kinetic resolution of 3-substituted cyclohexanones and desymmetrization of meso-disubstituted cycloketones.

Authors:  Wangbin Wu; Weidi Cao; Linfeng Hu; Zhishan Su; Xiaohua Liu; Xiaoming Feng
Journal:  Chem Sci       Date:  2019-06-10       Impact factor: 9.825
  4 in total

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