Literature DB >> 20821791

High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex.

Laura K Henchey1, Jason R Porter, Indraneel Ghosh, Paramjit S Arora.   

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Year:  2010        PMID： 20821791      PMCID： PMC3017812          DOI： 10.1002/cbic.201000378

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  44 in total

1.  Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based alpha helices.

Authors:  Deyun Wang; Min Lu; Paramjit S Arora
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 2.  Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

Authors:  James A Wells; Christopher L McClendon
Journal:  Nature       Date:  2007-12-13       Impact factor: 49.962

3.  Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.

Authors:  W Seth Horne; Lisa M Johnson; Thomas J Ketas; Per Johan Klasse; Min Lu; John P Moore; Samuel H Gellman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-17       Impact factor: 11.205

4.  A general and rapid cell-free approach for the interrogation of protein-protein, protein-DNA, and protein-RNA interactions and their antagonists utilizing split-protein reporters.

Authors:  Jason R Porter; Cliff I Stains; Benjamin W Jester; Indraneel Ghosh
Journal:  J Am Chem Soc       Date:  2008-04-29       Impact factor: 15.419

5.  Assessment of helical interfaces in protein-protein interactions.

Authors:  Andrea L Jochim; Paramjit S Arora
Journal:  Mol Biosyst       Date:  2009-04-08

6.  Beta-peptidic peptidomimetics.

Authors:  Dieter Seebach; James Gardiner
Journal:  Acc Chem Res       Date:  2008-06-26       Impact factor: 22.384

7.  Foldamers with heterogeneous backbones.

Authors:  W Seth Horne; Samuel H Gellman
Journal:  Acc Chem Res       Date:  2008-07-01       Impact factor: 22.384

Review 8.  Contemporary strategies for the stabilization of peptides in the alpha-helical conformation.

Authors:  Laura K Henchey; Andrea L Jochim; Paramjit S Arora
Journal:  Curr Opin Chem Biol       Date:  2008-09-13       Impact factor: 8.822

Review 9.  Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.

Authors:  Sanjeev Shangary; Shaomeng Wang
Journal:  Annu Rev Pharmacol Toxicol       Date:  2009       Impact factor: 13.820

10.  A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation.

Authors:  Anupam Patgiri; Andrea L Jochim; Paramjit S Arora
Journal:  Acc Chem Res       Date:  2008-07-17       Impact factor: 22.384
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  31 in total

1.  Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices.

Authors:  Andrew B Mahon; Paramjit S Arora
Journal:  Chem Commun (Camb)       Date:  2011-09-28       Impact factor: 6.222

2.  Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids.

Authors:  John R Frost; Nicholas T Jacob; Louis J Papa; Andrew E Owens; Rudi Fasan
Journal:  ACS Chem Biol       Date:  2015-05-15       Impact factor: 5.100

Review 3.  Inhibition of α-helix-mediated protein-protein interactions using designed molecules.

Authors:  Valeria Azzarito; Kérya Long; Natasha S Murphy; Andrew J Wilson
Journal:  Nat Chem       Date:  2013-03       Impact factor: 24.427

4.  Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions.

Authors:  Stephen E Miller; Paul F Thomson; Paramjit S Arora
Journal:  Curr Protoc Chem Biol       Date:  2014-06-03

5.  Effects of side chains in helix nucleation differ from helix propagation.

Authors:  Stephen E Miller; Andrew M Watkins; Neville R Kallenbach; Paramjit S Arora
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-21       Impact factor: 11.205

6.  Reversible α-helix formation controlled by a hydrogen bond surrogate.

Authors:  Stephen E Miller; Neville R Kallenbach; Paramjit S Arora
Journal:  Tetrahedron       Date:  2011-12-29       Impact factor: 2.457

7.  Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.

Authors:  Melissa D Boersma; Holly S Haase; Kimberly J Peterson-Kaufman; Erinna F Lee; Oliver B Clarke; Peter M Colman; Brian J Smith; W Seth Horne; W Douglas Fairlie; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2011-12-08       Impact factor: 15.419

8.  Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.

Authors:  Jessica M Smith; John R Frost; Rudi Fasan
Journal:  Chem Commun (Camb)       Date:  2014-04-07       Impact factor: 6.222

9.  End-Capped α-Helices as Modulators of Protein Function.

Authors:  Andrew B Mahon; Paramjit S Arora
Journal:  Drug Discov Today Technol       Date:  2012

Review 10.  Protein Domain Mimics as Modulators of Protein-Protein Interactions.

Authors:  Nicholas Sawyer; Andrew M Watkins; Paramjit S Arora
Journal:  Acc Chem Res       Date:  2017-05-31       Impact factor: 22.384
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