| Literature DB >> 2081972 |
L N Shih1, J C Sheu, J T Wang, G T Huang, P M Yang, H S Lee, J L Sung, T H Wang, D S Chen.
Abstract
Serum hepatitis B virus (HBV) DNA was assayed using polymerase chain reaction, in 107 HBsAg-negative normal Chinese subjects. The results showed that eight subjects (7.5%) had HBV DNA. In the subgroup with antibody to hepatitis B surface antigen (anti-HBs) and to hepatitis B core antigen (anti-HBc), 7.3% (5/68) were positive for HBV DNA; HBV DNA was not detected in six individuals with anti-HBs only and in nine with anti-HBc only. In four persons with anti-HBc and anti-HBe, one had HBV DNA. In 20 subjects negative for all hepatitis B serological markers, two (10%) were found to have HBV DNA. This study indicates that serological markers are not adequate to rule out HBV infection, and it further implies that present blood donor screening methods may need improving.Entities:
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Year: 1990 PMID： 2081972 DOI： 10.1002/jmv.1890320412
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327