AIM: To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis. METHODS: We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for genotypes GG/T vs T/T, GG/GG vs T/T, GG/T + GG/GG vs T/T, GG/GG vs T/T + GG/T, and GG allele vs T allele in a fixed/random effect model. RESULTS: We identified 8 studies (6439 cases and 4798 controls) in Caucasian populations using PubMed search. We found no association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease, Crohn's disease, and ulcerative colitis. Stratification of cases by age showed that NOD1/CARD4 insertion/deletion polymorphism was associated with inflammatory bowel disease in younger age group at onset (< 40 years) (GG vs T: OR = 0.68, 95% CI: 0.50-0.93, P = 0.02; GG/T + GG/GG vs T/T: OR = 0.71, 95% CI: 0.59-0.85, P = 0.0003). CONCLUSION: This meta-analysis demonstrates an association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease in the younger age group at onset (< 40 years) in Caucasian populations.
AIM: To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis. METHODS: We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for genotypes GG/T vs T/T, GG/GG vs T/T, GG/T + GG/GG vs T/T, GG/GG vs T/T + GG/T, and GG allele vs T allele in a fixed/random effect model. RESULTS: We identified 8 studies (6439 cases and 4798 controls) in Caucasian populations using PubMed search. We found no association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease, Crohn's disease, and ulcerative colitis. Stratification of cases by age showed that NOD1/CARD4 insertion/deletion polymorphism was associated with inflammatory bowel disease in younger age group at onset (< 40 years) (GG vs T: OR = 0.68, 95% CI: 0.50-0.93, P = 0.02; GG/T + GG/GG vs T/T: OR = 0.71, 95% CI: 0.59-0.85, P = 0.0003). CONCLUSION: This meta-analysis demonstrates an association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease in the younger age group at onset (< 40 years) in Caucasian populations.
Authors: H Zouali; S Lesage; F Merlin; J-P Cézard; J-F Colombel; J Belaiche; S Almer; C Tysk; C O'Morain; M Gassull; S Christensen; Y Finkel; R Modigliani; C Gower-Rousseau; J Macry; M Chamaillard; G Thomas; J-P Hugot Journal: Gut Date: 2003-01 Impact factor: 23.059
Authors: T Molnar; P Hofner; F Nagy; P L Lakatos; S Fischer; L Lakatos; A Kovacs; I Altorjay; M Papp; K Palatka; P Demeter; Z Tulassay; T Nyari; P Miheller; J Papp; Y Mandi; J Lonovics Journal: Dig Liver Dis Date: 2007-10-26 Impact factor: 4.088
Authors: Joerg Ermann; Tracy Staton; Jonathan N Glickman; Rene de Waal Malefyt; Laurie H Glimcher Journal: Proc Natl Acad Sci U S A Date: 2014-06-09 Impact factor: 11.205
Authors: Ivan Branković; Eleanne F van Ess; Marlies P Noz; Wilhelmina Anke J Wiericx; Joke Spaargaren; Servaas A Morré; Sander Ouburg Journal: Pathog Dis Date: 2015-01-11 Impact factor: 3.166
Authors: Gijs Th J van Well; Marieke S Sanders; Sander Ouburg; A Marceline van Furth; Servaas A Morré Journal: PLoS One Date: 2012-05-25 Impact factor: 3.240