| Literature DB >> 20817521 |
Craig Jamieson1, Robert A Campbell, Iain A Cumming, Kevin J Gillen, Jonathan Gillespie, Bert Kazemier, Michael Kiczun, Yvonne Lamont, Amanda J Lyons, John K F Maclean, Frederic Martin, Elizabeth M Moir, John A Morrow, John Pantling, Zoran Rankovic, Lynn Smith.
Abstract
Starting from lead compound 1, we demonstrate how X-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20817521 DOI： 10.1016/j.bmcl.2010.08.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823