OBJECTIVE: To compare two semiquantitative scoring systems for assessing the prevalence and severity of morphologic cartilage lesions, meniscal damage and bone marrow lesions (BMLs) from Magnetic Resonance Imagings (MRIs) of knees with osteoarthritis (OA). METHODS: From participants in the OA Initiative (OAI), a sample of 115 knees with radiographic OA at high risk of cartilage loss, were selected based on risk factors for progression. Knee MRIs were read separately using both Whole Organ MR Scoring (WORMS) and Boston-Leeds OA Knee Scoring (BLOKS), and a subset was fed back to readers for reliability. Baseline readings were used for comparison of the two methods for inter-reader reliability as well as agreement on presence/absence and severity of MRI features at both the compartment level and finer anatomical subregion levels. RESULTS: Both methods had high inter-reader agreement for all features studied (kappa for WORMS 0.69-1.0 and for BLOKS 0.65-1.0). Although the methods agreed well on presence and severity of morphological cartilage lesions (inter-method kappas from 0.66 to 0.95), BLOKS was more sensitive for full thickness defects. The two methods gave equivalent results for extent (kappa 0.74-0.80) and number (Spearman's Rho=0.85) of BMLs, and little extra information was obtained using the more complex BLOKS BML scoring. Similar results were also obtained for the common types of meniscal damage and extrusion (inter-method kappa 0.85-0.94), but the inclusion in BLOKS of meniscal signal abnormality and uncommon types of tear may be an advantage if these prove clinically meaningful. CONCLUSION: Both WORMS and BLOKS had high reliability. The two methods gave similar results in this sample for prevalence and severity of cartilage loss, BMLs and meniscal damage. Selecting between, or combining, the two methods should be based on factors such as reader effort, appropriateness for the goals of a study, and longitudinal performance.
OBJECTIVE: To compare two semiquantitative scoring systems for assessing the prevalence and severity of morphologic cartilage lesions, meniscal damage and bone marrow lesions (BMLs) from Magnetic Resonance Imagings (MRIs) of knees with osteoarthritis (OA). METHODS: From participants in the OA Initiative (OAI), a sample of 115 knees with radiographic OA at high risk of cartilage loss, were selected based on risk factors for progression. Knee MRIs were read separately using both Whole Organ MR Scoring (WORMS) and Boston-Leeds OA Knee Scoring (BLOKS), and a subset was fed back to readers for reliability. Baseline readings were used for comparison of the two methods for inter-reader reliability as well as agreement on presence/absence and severity of MRI features at both the compartment level and finer anatomical subregion levels. RESULTS: Both methods had high inter-reader agreement for all features studied (kappa for WORMS 0.69-1.0 and for BLOKS 0.65-1.0). Although the methods agreed well on presence and severity of morphological cartilage lesions (inter-method kappas from 0.66 to 0.95), BLOKS was more sensitive for full thickness defects. The two methods gave equivalent results for extent (kappa 0.74-0.80) and number (Spearman's Rho=0.85) of BMLs, and little extra information was obtained using the more complex BLOKS BML scoring. Similar results were also obtained for the common types of meniscal damage and extrusion (inter-method kappa 0.85-0.94), but the inclusion in BLOKS of meniscal signal abnormality and uncommon types of tear may be an advantage if these prove clinically meaningful. CONCLUSION: Both WORMS and BLOKS had high reliability. The two methods gave similar results in this sample for prevalence and severity of cartilage loss, BMLs and meniscal damage. Selecting between, or combining, the two methods should be based on factors such as reader effort, appropriateness for the goals of a study, and longitudinal performance.
Authors: David T Felson; Jingbo Niu; Ali Guermazi; Frank Roemer; Piran Aliabadi; Margaret Clancy; James Torner; C Elizabeth Lewis; Michael C Nevitt Journal: Arthritis Rheum Date: 2007-09
Authors: Shreyasee Amin; Michael P LaValley; Ali Guermazi; Mikayel Grigoryan; David J Hunter; Margaret Clancy; Jingbo Niu; Daniel R Gale; David T Felson Journal: Arthritis Rheum Date: 2005-10
Authors: Grace H Lo; David J Hunter; Yuqing Zhang; Christine E McLennan; Michael P Lavalley; Douglas P Kiel; Robert R McLean; Harry K Genant; Ali Guermazi; David T Felson Journal: Arthritis Rheum Date: 2005-09
Authors: Laura D Carbone; Michael C Nevitt; Kathryn Wildy; Karen D Barrow; Fran Harris; David Felson; Charles Peterfy; Marjolein Visser; Tamara B Harris; Benjamin W E Wang; Stephen B Kritchevsky Journal: Arthritis Rheum Date: 2004-11
Authors: Peter R Kornaat; Ruth Y T Ceulemans; Herman M Kroon; Naghmeh Riyazi; Margreet Kloppenburg; Wayne O Carter; Thasia G Woodworth; Johan L Bloem Journal: Skeletal Radiol Date: 2004-10-08 Impact factor: 2.199
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: Martin Englund; Ali Guermazi; Frank W Roemer; Piran Aliabadi; Mei Yang; Cora E Lewis; James Torner; Michael C Nevitt; Burton Sack; David T Felson Journal: Arthritis Rheum Date: 2009-03
Authors: F W Roemer; D J Hunter; M D Crema; C K Kwoh; E Ochoa-Albiztegui; A Guermazi Journal: Osteoarthritis Cartilage Date: 2015-08-28 Impact factor: 6.576
Authors: Constance R Chu; Bruce D Beynnon; Joseph A Buckwalter; William E Garrett; Jeffrey N Katz; Scott A Rodeo; Kurt P Spindler; Robert A Stanton Journal: Am J Sports Med Date: 2011-07 Impact factor: 6.202
Authors: Thomas Baum; Gabby B Joseph; Lorenzo Nardo; Warapat Virayavanich; Ahilan Arulanandan; Hamza Alizai; Julio Carballido-Gamio; Michael C Nevitt; John Lynch; Charles E McCulloch; Thomas M Link Journal: Arthritis Care Res (Hoboken) Date: 2013-01 Impact factor: 4.794
Authors: D T Felson; J Niu; T Neogi; J Goggins; M C Nevitt; F Roemer; J Torner; C E Lewis; A Guermazi Journal: Osteoarthritis Cartilage Date: 2015-09-30 Impact factor: 6.576
Authors: Isabel A C Baert; Filip Staes; Steven Truijen; Armaghan Mahmoudian; Nathalie Noppe; Geert Vanderschueren; Frank P Luyten; Sabine M P Verschueren Journal: Knee Surg Sports Traumatol Arthrosc Date: 2013-02-02 Impact factor: 4.342
Authors: David T Felson; Jingbo Niu; K Douglas Gross; Martin Englund; Leena Sharma; T Derek V Cooke; Ali Guermazi; Frank W Roemer; Neil Segal; Joyce M Goggins; C Elizabeth Lewis; Charles Eaton; Michael C Nevitt Journal: Arthritis Rheum Date: 2013-02