OBJECTIVE: We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain. STUDY DESIGN: A total of 960 participants in the Pregnancy, Infection, and Nutrition cohorts were genotyped for 27 single-nucleotide polymorphisms (SNPs) associated with diabetes and obesity. RESULTS: Among Caucasian and African American women (n = 960), KCNQ1 risk allele carriage was directly associated with weight gain (P < .01). In Bayesian hierarchical models among Caucasian women (n = 628), we found posterior odds ratios >3 for inclusion of TCF2 and THADA SNPs in our models. Among African American women (n = 332), we found associations between risk allele carriage and weight gain for the THADA and INSIG2 SNPs. In Bayesian variable selection models, we found an interaction between the TSPAN8 risk allele and pregravid obesity, with lower weight gain among obese risk allele carriers. CONCLUSION: We found evidence that diabetes and obesity risk alleles interact with maternal pregravid body mass index to predict gestational weight gain. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain. STUDY DESIGN: A total of 960 participants in the Pregnancy, Infection, and Nutrition cohorts were genotyped for 27 single-nucleotide polymorphisms (SNPs) associated with diabetes and obesity. RESULTS: Among Caucasian and African American women (n = 960), KCNQ1 risk allele carriage was directly associated with weight gain (P < .01). In Bayesian hierarchical models among Caucasian women (n = 628), we found posterior odds ratios >3 for inclusion of TCF2 and THADA SNPs in our models. Among African American women (n = 332), we found associations between risk allele carriage and weight gain for the THADA and INSIG2 SNPs. In Bayesian variable selection models, we found an interaction between the TSPAN8 risk allele and pregravid obesity, with lower weight gain among obese risk allele carriers. CONCLUSION: We found evidence that diabetes and obesity risk alleles interact with maternal pregravid body mass index to predict gestational weight gain. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: Emily Oken; Elsie M Taveras; Ken P Kleinman; Janet W Rich-Edwards; Matthew W Gillman Journal: Am J Obstet Gynecol Date: 2007-04 Impact factor: 8.661
Authors: Catarina D Campbell; Helen N Lyon; James Nemesh; Jared A Drake; Tiinamaija Tuomi; Daniel Gaudet; Xiaofeng Zhu; Richard S Cooper; Kristin G Ardlie; Leif C Groop; Joel N Hirschhorn Journal: Diabetes Date: 2007-02-26 Impact factor: 9.461
Authors: Alan Herbert; Norman P Gerry; Matthew B McQueen; Iris M Heid; Arne Pfeufer; Thomas Illig; H-Erich Wichmann; Thomas Meitinger; David Hunter; Frank B Hu; Graham Colditz; Anke Hinney; Johannes Hebebrand; Kerstin Koberwitz; Xiaofeng Zhu; Richard Cooper; Kristin Ardlie; Helen Lyon; Joel N Hirschhorn; Nan M Laird; Marc E Lenburg; Christoph Lange; Michael F Christman Journal: Science Date: 2006-04-14 Impact factor: 47.728
Authors: Zofia K Z Gajdos; Johannah L Butler; Katherine DeLellis Henderson; Chunyan He; Pamela J Supelak; Matthew Egyud; Alkes Price; David Reich; Peter E Clayton; Loic Le Marchand; David J Hunter; Brian E Henderson; Mark R Palmert; Joel N Hirschhorn Journal: J Clin Endocrinol Metab Date: 2008-08-26 Impact factor: 5.958
Authors: Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy Journal: Science Date: 2007-04-12 Impact factor: 47.728
Authors: Helen N Lyon; Valur Emilsson; Anke Hinney; Iris M Heid; Jessica Lasky-Su; Xiaofeng Zhu; Gudmar Thorleifsson; Steinunn Gunnarsdottir; G Bragi Walters; Unnur Thorsteinsdottir; Augustine Kong; Jeffrey Gulcher; Thuy Trang Nguyen; André Scherag; Arne Pfeufer; Thomas Meitinger; Günter Brönner; Winfried Rief; Manuel E Soto-Quiros; Lydiana Avila; Barbara Klanderman; Benjamin A Raby; Edwin K Silverman; Scott T Weiss; Nan Laird; Xiao Ding; Leif Groop; Tiinamaija Tuomi; Bo Isomaa; Kristina Bengtsson; Johannah L Butler; Richard S Cooper; Caroline S Fox; Christopher J O'Donnell; Caren Vollmert; Juan C Celedón; H Erich Wichmann; Johannes Hebebrand; Kari Stefansson; Christoph Lange; Joel N Hirschhorn Journal: PLoS Genet Date: 2007-03-07 Impact factor: 5.917
Authors: Vivian K Kawai; Samuel K Nwosu; Daniel Kurnik; Frank E Harrell; C Michael Stein Journal: Obesity (Silver Spring) Date: 2019-05-22 Impact factor: 5.002
Authors: Debbie A Lawlor; Abigail Fraser; Corrie Macdonald-Wallis; Scott M Nelson; Tom M Palmer; George Davey Smith; Kate Tilling Journal: Am J Clin Nutr Date: 2011-05-18 Impact factor: 7.045
Authors: Xinyi Lin; Izzuddin M Aris; Mya Thway Tint; Shu E Soh; Keith M Godfrey; George Seow-Heong Yeo; Kenneth Kwek; Jerry Kok-Yen Chan; Peter D Gluckman; Yap Seng Chong; Fabian Yap; Joanna D Holbrook; Yung Seng Lee Journal: J Clin Endocrinol Metab Date: 2015-07-22 Impact factor: 5.958