OBJECTIVE: The aim of this study in goats was to test the hypothesis that a novel synthetic bone substitute beta tricalcium phosphate (β-TCP) can work as well as autologous bone harvested from the iliac crest for grafting and repair of alveolar clefts. DESIGN: Ten adult Dutch milk goats (Capra hircus) were used in a split-mouth study design. MAIN OUTCOME MEASURES: Volumetric histologic assessment of new bone formation and radiographic measurement of orthodontic movement of teeth in a formerly created alveolar cleft. CONCLUSIONS: The synthetic bone substitute β-TCP was shown to result in bone healing similar to that of iliac crest bone. The surgical, orthodontic, and histologic results now warrant the testing of β-TCP in the human cleft situation.
OBJECTIVE: The aim of this study in goats was to test the hypothesis that a novel synthetic bone substitute beta tricalcium phosphate (β-TCP) can work as well as autologous bone harvested from the iliac crest for grafting and repair of alveolar clefts. DESIGN: Ten adult Dutch milk goats (Capra hircus) were used in a split-mouth study design. MAIN OUTCOME MEASURES: Volumetric histologic assessment of new bone formation and radiographic measurement of orthodontic movement of teeth in a formerly created alveolar cleft. CONCLUSIONS: The synthetic bone substitute β-TCP was shown to result in bone healing similar to that of iliac crest bone. The surgical, orthodontic, and histologic results now warrant the testing of β-TCP in the human cleft situation.
Authors: Montserrat Caballero; Justin C Morse; Alexandra E Halevi; Omri Emodi; Michael R Pharaon; Jeyhan S Wood; John A van Aalst Journal: Tissue Eng Part C Methods Date: 2015-09 Impact factor: 3.056
Authors: Mohammad Kamal; Lars Andersson; Rene Tolba; Adel Al-Asfour; Alexander K Bartella; Felix Gremse; Stefanie Rosenhain; Frank Hölzle; Peter Kessler; Bernd Lethaus Journal: J Transl Med Date: 2017-12-23 Impact factor: 5.531
Authors: Mohammad Kamal; Lars Andersson; Rene Tolba; Alexander Bartella; Felix Gremse; Frank Hölzle; Peter Kessler; Bernd Lethaus Journal: J Transl Med Date: 2017-02-24 Impact factor: 5.531
Authors: Stephan Christian Möhlhenrich; Kristian Kniha; Zuzanna Magnuska; Sachin Chhatwani; Benita Hermanns-Sachweh; Felix Gremse; Frank Hölzle; Gholamreza Danesh; Ali Modabber Journal: Clin Oral Investig Date: 2022-05-14 Impact factor: 3.606
Authors: Stephan Christian Möhlhenrich; Kristian Kniha; Zuzanna Magnuska; Benita Hermanns-Sachweh; Felix Gremse; Frank Hölzle; Gholamreza Danesh; Ali Modabber Journal: Sci Rep Date: 2021-06-30 Impact factor: 4.379