Literature DB >> 20814252

Behavioral genetic approach to the study of dyslexia.

Brooke Soden Hensler1, Christopher Schatschneider, Jeanette Taylor, Richard K Wagner.   

Abstract

OBJECTIVE: Dyslexia is a prominent focus of practitioners, educators, and researchers because of the myriad consequences of failing to read proficiently. The aim of this study was to provide a brief overview of how twin studies can offer insight on the cause of many human behaviors and disorders including dyslexia, discuss common misconceptions regarding findings from behavioral genetic studies, briefly review the evidence on the relationship between genes, environment, and dyslexia, and finally present some findings from a large-scale twin study on reading and dyslexia.
METHOD: Participants were twins from a large ethnically and socioeconomically diverse twin sample in an ongoing longitudinal study of reading and dyslexia. Heritabilities of reading ability and dyslexia were calculated for 1,024 first grade twins on a standardized reading measure. Children were identified as dyslexic if they scored at the 15th percentile or below on a reading measure.
RESULTS: Relatively high heritabilities were observed for both reading ability and dyslexia indicating substantial genetic influences. Further, results indicated some overlap of genetic factors influencing reading ability and dyslexia.
CONCLUSIONS: Behavioral genetic studies offer a means of understanding the cause of dyslexia. This study extended research to a more diverse sample than extant studies and found lower heritability estimates of reading ability and dyslexia, but a similar pattern of results indicating possible genetic overlap. Twin studies provide perspective for discoveries of specific genes involved in dyslexia by quantifying the amount of variance waiting to be accounted for by genes while simultaneously providing an impetus to continue working on efforts for environmental intervention.

Entities:  

Mesh:

Year:  2010        PMID: 20814252      PMCID: PMC2952936          DOI: 10.1097/DBP.0b013e3181ee4b70

Source DB:  PubMed          Journal:  J Dev Behav Pediatr        ISSN: 0196-206X            Impact factor:   2.225


  30 in total

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2.  Genetic and environmental influences on individual differences in printed word recognition.

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Review 3.  Genetic and environmental influences on early speech, language and literacy development.

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Journal:  J Child Psychol Psychiatry       Date:  2005-04       Impact factor: 8.982

5.  Evidence that dyslexia may represent the lower tail of a normal distribution of reading ability.

Authors:  S E Shaywitz; M D Escobar; B A Shaywitz; J M Fletcher; R Makuch
Journal:  N Engl J Med       Date:  1992-01-16       Impact factor: 91.245

Review 6.  Generalist genes and learning disabilities.

Authors:  Robert Plomin; Yulia Kovas
Journal:  Psychol Bull       Date:  2005-07       Impact factor: 17.737

Review 7.  Dyslexia: a new synergy between education and cognitive neuroscience.

Authors:  John D E Gabrieli
Journal:  Science       Date:  2009-07-17       Impact factor: 47.728

8.  Genetic influences on reading difficulties in boys and girls: the Colorado twin study.

Authors:  Jesse L Hawke; Sally J Wadsworth; John C DeFries
Journal:  Dyslexia       Date:  2006-02

Review 9.  Specific reading disability (dyslexia): what have we learned in the past four decades?

Authors:  Frank R Vellutino; Jack M Fletcher; Margaret J Snowling; Donna M Scanlon
Journal:  J Child Psychol Psychiatry       Date:  2004-01       Impact factor: 8.982

10.  Genetic and Environmental Influences on Aspects of Literacy and Language in Early Childhood: Continuity and Change from Preschool to Grade 2.

Authors:  Brian Byrne; William L Coventry; Richard K Olson; Stefan Samuelsson; Robin Corley; Erik G Willcutt; Sally Wadsworth; John C Defries
Journal:  J Neurolinguistics       Date:  2009-05       Impact factor: 1.710

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  3 in total

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2.  An update on the Florida State Twin Registry.

Authors:  Jeanette E Taylor; Sara A Hart; Amy J Mikolajewski; Christopher Schatschneider
Journal:  Twin Res Hum Genet       Date:  2012-10-15       Impact factor: 1.587

3.  Enhanced recognition memory after incidental encoding in children with developmental dyslexia.

Authors:  Martina Hedenius; Michael T Ullman; Per Alm; Margareta Jennische; Jonas Persson
Journal:  PLoS One       Date:  2013-05-23       Impact factor: 3.240

  3 in total

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