Literature DB >> 20813241

Using expression genetics to study the neurobiology of ethanol and alcoholism.

Sean P Farris1, Aaron R Wolen, Michael F Miles.   

Abstract

Recent simultaneous progress in human and animal model genetics and the advent of microarray whole genome expression profiling have produced prodigious data sets on genetic loci, potential candidate genes, and differential gene expression related to alcoholism and ethanol behaviors. Validated target genes or gene networks functioning in alcoholism are still of meager proportions. Genetical genomics, which combines genetic analysis of both traditional phenotypes and whole genome expression data, offers a potential methodology for characterizing brain gene networks functioning in alcoholism. This chapter will describe concepts, approaches, and recent findings in the field of genetical genomics as it applies to alcohol research. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20813241      PMCID： PMC3427772          DOI： 10.1016/S0074-7742(10)91004-0

Source DB:  PubMed          Journal:  Int Rev Neurobiol        ISSN： 0074-7742            Impact factor:   3.230


  101 in total

1.  An integrative genomics approach to infer causal associations between gene expression and disease.

Authors:  Eric E Schadt; John Lamb; Xia Yang; Jun Zhu; Steve Edwards; Debraj Guhathakurta; Solveig K Sieberts; Stephanie Monks; Marc Reitman; Chunsheng Zhang; Pek Yee Lum; Amy Leonardson; Rolf Thieringer; Joseph M Metzger; Liming Yang; John Castle; Haoyuan Zhu; Shera F Kash; Thomas A Drake; Alan Sachs; Aldons J Lusis
Journal:  Nat Genet       Date:  2005-06-19       Impact factor: 38.330

2.  affyGG: computational protocols for genetical genomics with Affymetrix arrays.

Authors:  Rudi Alberts; Gonzalo Vera; Ritsert C Jansen
Journal:  Bioinformatics       Date:  2007-12-16       Impact factor: 6.937

3.  Expression of MBP, PLP, MAG, CNP, and GFAP in the Human Alcoholic Brain.

Authors:  Joanne M Lewohl; Julie Wixey; Clive G Harper; Peter R Dodd
Journal:  Alcohol Clin Exp Res       Date:  2005-09       Impact factor: 3.455

4.  Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization.

Authors:  Y Xu; M Ehringer; F Yang; J M Sikela
Journal:  Alcohol Clin Exp Res       Date:  2001-06       Impact factor: 3.455

5.  Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.

Authors:  D W Bailey
Journal:  Transplantation       Date:  1971-03       Impact factor: 4.939

6.  Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins.

Authors:  C A Prescott; S H Aggen; K S Kendler
Journal:  Alcohol Clin Exp Res       Date:  1999-07       Impact factor: 3.455

7.  Neuronal counts from four cortical regions of alcoholic brains.

Authors:  J J Kril; C G Harper
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

8.  Ontological Discovery Environment: a system for integrating gene-phenotype associations.

Authors:  Erich J Baker; Jeremy J Jay; Vivek M Philip; Yun Zhang; Zuopan Li; Roumyana Kirova; Michael A Langston; Elissa J Chesler
Journal:  Genomics       Date:  2009-09-03       Impact factor: 5.736

9.  ERGR: An ethanol-related gene resource.

Authors:  An-Yuan Guo; Bradley T Webb; Michael F Miles; Mark P Zimmerman; Kenneth S Kendler; Zhongming Zhao
Journal:  Nucleic Acids Res       Date:  2008-10-31       Impact factor: 16.971

10.  A new set of BXD recombinant inbred lines from advanced intercross populations in mice.

Authors:  Jeremy L Peirce; Lu Lu; Jing Gu; Lee M Silver; Robert W Williams
Journal:  BMC Genet       Date:  2004-04-29       Impact factor: 2.797
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  16 in total

Review 1.  Applying the new genomics to alcohol dependence.

Authors:  Sean P Farris; Andrzej Z Pietrzykowski; Michael F Miles; Megan A O'Brien; Pietro P Sanna; Samir Zakhari; R Dayne Mayfield; R Adron Harris
Journal:  Alcohol       Date:  2015-03-28       Impact factor: 2.405

2.  Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain.

Authors:  Candice Contet
Journal:  Curr Psychopharmacol       Date:  2012-11

Review 3.  Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

Authors:  Richard L Bell; Helen J K Sable; Giancarlo Colombo; Petri Hyytia; Zachary A Rodd; Lawrence Lumeng
Journal:  Pharmacol Biochem Behav       Date:  2012-07-25       Impact factor: 3.533

Review 4.  Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system.

Authors:  Tatjana Yakovleva; Igor Bazov; Hiroyuki Watanabe; Kurt F Hauser; Georgy Bakalkin
Journal:  Brain Behav Immun       Date:  2010-12-30       Impact factor: 7.217

5.  Substitute of Animals in Drug Research: An Approach Towards Fulfillment of 4R's.

Authors:  T Arora; A K Mehta; V Joshi; K D Mehta; N Rathor; P K Mediratta; K K Sharma
Journal:  Indian J Pharm Sci       Date:  2011-01       Impact factor: 0.975

6.  Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks.

Authors:  Elizabeth A Osterndorff-Kahanek; Howard C Becker; Marcelo F Lopez; Sean P Farris; Gayatri R Tiwari; Yury O Nunez; R Adron Harris; R Dayne Mayfield
Journal:  PLoS One       Date:  2015-03-24       Impact factor: 3.240

7.  Transcriptome organization for chronic alcohol abuse in human brain.

Authors:  S P Farris; D Arasappan; S Hunicke-Smith; R A Harris; R D Mayfield
Journal:  Mol Psychiatry       Date:  2014-12-02       Impact factor: 15.992

8.  Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: comparison with immune activation.

Authors:  Elizabeth Osterndorff-Kahanek; Igor Ponomarev; Yuri A Blednov; R Adron Harris
Journal:  PLoS One       Date:  2013-03-29       Impact factor: 3.240

9.  Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence.

Authors:  Mohammed Mamdani; Vernell Williamson; Gowon O McMichael; Tana Blevins; Fazil Aliev; Amy Adkins; Laura Hack; Tim Bigdeli; Andrew D van der Vaart; Bradley Todd Web; Silviu-Alin Bacanu; Gursharan Kalsi; Kenneth S Kendler; Michael F Miles; Danielle Dick; Brien P Riley; Catherine Dumur; Vladimir I Vladimirov
Journal:  PLoS One       Date:  2015-09-18       Impact factor: 3.240

10.  Assessing the genetic risk for alcohol use disorders.

Authors:  Tatiana Foroud; Tamara J Phillips
Journal:  Alcohol Res       Date:  2012
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