BACKGROUND AND AIM: Knowledge about the genetic factors responsible for noise-induced hearing loss (NIHL) is still limited. This study investigated whether genetic factors are associated or not to susceptibility to NIHL. SUBJECTS AND METHODS: The family history and genotypes were studied for candidate genes in 107 individuals with NIHL, 44 with other causes of hearing impairment and 104 controls. Mutations frequently found among deaf individuals were investigated (35delG, 167delT in GJB2, Δ(GJB6- D13S1830), Δ(GJB6- D13S1854) in GJB6 and A1555G in MT-RNR1 genes); allelic and genotypic frequencies were also determined at the SNP rs877098 in DFNB1, of deletions of GSTM1 and GSTT1 and sequence variants in both MTRNR1 and MTTS1 genes, as well as mitochondrial haplogroups. RESULTS: When those with NIHL were compared with the control group, a significant increase was detected in the number of relatives affected by hearing impairment, of the genotype corresponding to the presence of both GSTM1 and GSTT1 enzymes and of cases with mitochondrial haplogroup L1. CONCLUSION: The findings suggest effects of familial history of hearing loss, of GSTT1 and GSTM1 enzymes and of mitochondrial haplogroup L1 on the risk of NIHL. This study also described novel sequence variants of MTRNR1 and MTTS1 genes.
BACKGROUND AND AIM: Knowledge about the genetic factors responsible for noise-induced hearing loss (NIHL) is still limited. This study investigated whether genetic factors are associated or not to susceptibility to NIHL. SUBJECTS AND METHODS: The family history and genotypes were studied for candidate genes in 107 individuals with NIHL, 44 with other causes of hearing impairment and 104 controls. Mutations frequently found among deaf individuals were investigated (35delG, 167delT in GJB2, Δ(GJB6- D13S1830), Δ(GJB6- D13S1854) in GJB6 and A1555G in MT-RNR1 genes); allelic and genotypic frequencies were also determined at the SNP rs877098 in DFNB1, of deletions of GSTM1 and GSTT1 and sequence variants in both MTRNR1 and MTTS1 genes, as well as mitochondrial haplogroups. RESULTS: When those with NIHL were compared with the control group, a significant increase was detected in the number of relatives affected by hearing impairment, of the genotype corresponding to the presence of both GSTM1 and GSTT1 enzymes and of cases with mitochondrial haplogroup L1. CONCLUSION: The findings suggest effects of familial history of hearing loss, of GSTT1 and GSTM1 enzymes and of mitochondrial haplogroup L1 on the risk of NIHL. This study also described novel sequence variants of MTRNR1 and MTTS1 genes.
Authors: Susan L Phillips; Scott J Richter; Sandra L Teglas; Ishan S Bhatt; Robin C Morehouse; Elizabeth R Hauser; Vincent C Henrich Journal: Int J Audiol Date: 2015-05-04 Impact factor: 2.117
Authors: Yohann Grondin; Magda E Bortoni; Rosalinda Sepulveda; Elisa Ghelfi; Adam Bartos; Douglas Cotanche; Royce E Clifford; Rick A Rogers Journal: PLoS One Date: 2015-06-29 Impact factor: 3.240
Authors: Ana Paula Grillo; Flávia Marcorin de Oliveira; Gabriela Queila de Carvalho; Ruan Felipe Vieira Medrano; Sueli Matilde da Silva-Costa; Edi Lúcia Sartorato; Camila Andréa de Oliveira Journal: Biomed Res Int Date: 2015-05-17 Impact factor: 3.411
Authors: Massimo Ralli; Maria Paola Balla; Antonio Greco; Giancarlo Altissimi; Pasquale Ricci; Rosaria Turchetta; Armando de Virgilio; Marco de Vincentiis; Serafino Ricci; Giancarlo Cianfrone Journal: Int J Environ Res Public Health Date: 2017-09-08 Impact factor: 3.390