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Literature DB >> 20812024

FBI-1 functions as a novel AR co-repressor in prostate cancer cells.

Jiajun Cui¹, Yutao Yang, Chuanfu Zhang, Pinliang Hu, Wei Kan, Xianhong Bai, Xuelin Liu, Hongbin Song.

Abstract

The pro-oncogene FBI-1, encoded by Zbtb7a, is a transcriptional repressor that belongs to the POK (POZ/BTB and Krüppel) protein family. In this study, we investigated a potential interaction between androgen receptor (AR) signaling and FBI-1 and demonstrated that overexpression of FBI-1 inhibited ligand-dependent AR activation. A protein-protein interaction was identified between FBI-1 and AR in a ligand-dependent manner. Furthermore, FBI-1, AR and SMRT formed a ternary complex and FBI-1 enhanced the recruitment of NCoR and SMRT to endogenous PSA upstream sequences. Our data also indicated that the FBI-1-mediated inhibition of AR transcriptional activity is partially dependent on HDAC. Interestingly, FBI-1 plays distinct roles in regulating LNCaP (androgen-dependent) and PC-3 cell (androgen-independent) proliferation.

Entities: Chemical

Mesh：

Substances：

Year: 2010 PMID： 20812024 DOI： 10.1007/s00018-010-0511-7

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.207

38 in total

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