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Literature DB >> 23396304

Role of LRF/Pokemon in lineage fate decisions.

Andrea Lunardi¹, Jlenia Guarnerio, Guocan Wang, Takahiro Maeda, Pier Paolo Pandolfi.

Abstract

In the human genome, 43 different genes are found that encode proteins belonging to the family of the POK (poxvirus and zinc finger and Krüppel)/ZBTB (zinc finger and broad complex, tramtrack, and bric à brac) factors. Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/POK erythroid myeloid ontogenic factor, which is probably one of the most exciting and yet enigmatic members of the POK/ZBTB family.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23396304 PMCID： PMC3624932 DOI： 10.1182/blood-2012-11-292037

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

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