| Literature DB >> 20811987 |
Kevin M Sours1, Natalie G Ahn.
Abstract
Hydrogen exchange mass spectrometry (HX-MS) is an experimental technique that can be used to -examine solvent accessibility and conformational mobility in biological macromolecules. This chapter summarizes studies using HX-MS to examine the regulation of conformation, protein mobility, and ligand binding to MAP kinases. We describe the planning and design of HX-MS experiments, strategies for data analysis and interpretation, and available software.Entities:
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Year: 2010 PMID： 20811987 PMCID： PMC3252998 DOI： 10.1007/978-1-60761-795-2_14
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745