Literature DB >> 20810283

DNA methylation and cellular reprogramming.

Daniel D De Carvalho1, Jueng Soo You, Peter A Jones.   

Abstract

The recent discovery that a small number of defined factors are sufficient to reprogram somatic cells into pluripotent stem cells has significantly expanded our knowledge of the plasticity of the epigenome. In this review we discuss some aspects of cell fate plasticity and epigenetic alterations, with emphasis on DNA methylation during cellular reprogramming. Recent data suggest that DNA methylation is a major barrier to induced pluripotent stem (iPS) cell reprogramming. The demethylating agent 5-azacytidine can enhance the efficiency of iPS cells generation and the putative DNA demethylase protein activation-induced cytidine deaminase (AID/AICDA) can erase DNA methylation at pluripotency gene promoters, thereby allowing cellular reprogramming. Elucidation of the epigenetic changes taking place during cellular reprogramming will enhance our understanding of stem cell biology and facilitate therapeutic applications.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20810283      PMCID： PMC2981432          DOI： 10.1016/j.tcb.2010.08.003

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  85 in total

1.  Direct generation of ES-like cells from unmodified mouse embryonic fibroblasts by Oct4/Sox2/Myc/Klf4.

Authors:  Dajiang Qin; Wen Li; Jin Zhang; Duanqing Pei
Journal:  Cell Res       Date:  2007-11       Impact factor: 25.617

2.  Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.

Authors:  Matthias Stadtfeld; Nimet Maherali; David T Breault; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2008-02-14       Impact factor: 24.633

3.  Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Authors:  Nimet Maherali; Rupa Sridharan; Wei Xie; Jochen Utikal; Sarah Eminli; Katrin Arnold; Matthias Stadtfeld; Robin Yachechko; Jason Tchieu; Rudolf Jaenisch; Kathrin Plath; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2007-06-07       Impact factor: 24.633

4.  Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.

Authors:  Jacob Hanna; Marius Wernig; Styliani Markoulaki; Chiao-Wang Sun; Alexander Meissner; John P Cassady; Caroline Beard; Tobias Brambrink; Li-Chen Wu; Tim M Townes; Rudolf Jaenisch
Journal:  Science       Date:  2007-12-06       Impact factor: 47.728

5.  Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.

Authors:  Alexander Meissner; Marius Wernig; Rudolf Jaenisch
Journal:  Nat Biotechnol       Date:  2007-08-27       Impact factor: 54.908

6.  Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.

Authors:  Marius Wernig; Jian-Ping Zhao; Jan Pruszak; Eva Hedlund; Dongdong Fu; Frank Soldner; Vania Broccoli; Martha Constantine-Paton; Ole Isacson; Rudolf Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-07       Impact factor: 11.205

7.  Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

Authors:  Masato Nakagawa; Michiyo Koyanagi; Koji Tanabe; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Keisuke Okita; Yuji Mochiduki; Nanako Takizawa; Shinya Yamanaka
Journal:  Nat Biotechnol       Date:  2007-11-30       Impact factor: 54.908

8.  Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.

Authors:  Tarjei S Mikkelsen; Manching Ku; David B Jaffe; Biju Issac; Erez Lieberman; Georgia Giannoukos; Pablo Alvarez; William Brockman; Tae-Kyung Kim; Richard P Koche; William Lee; Eric Mendenhall; Aisling O'Donovan; Aviva Presser; Carsten Russ; Xiaohui Xie; Alexander Meissner; Marius Wernig; Rudolf Jaenisch; Chad Nusbaum; Eric S Lander; Bradley E Bernstein
Journal:  Nature       Date:  2007-07-01       Impact factor: 49.962

9.  Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.

Authors:  Lanlan Shen; Yutaka Kondo; Yi Guo; Jiexin Zhang; Li Zhang; Saira Ahmed; Jingmin Shu; Xinli Chen; Robert A Waterland; Jean-Pierre J Issa
Journal:  PLoS Genet       Date:  2007-09-10       Impact factor: 5.917

10.  A novel CpG island set identifies tissue-specific methylation at developmental gene loci.

Authors:  Robert Illingworth; Alastair Kerr; Dina Desousa; Helle Jørgensen; Peter Ellis; Jim Stalker; David Jackson; Chris Clee; Robert Plumb; Jane Rogers; Sean Humphray; Tony Cox; Cordelia Langford; Adrian Bird
Journal:  PLoS Biol       Date:  2008-01       Impact factor: 8.029
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  94 in total

Review 1.  Epigenetic control on cell fate choice in neural stem cells.

Authors:  Xiao-Ling Hu; Yuping Wang; Qin Shen
Journal:  Protein Cell       Date:  2012-05-02       Impact factor: 14.870

2.  DNA methylation screening identifies driver epigenetic events of cancer cell survival.

Authors:  Daniel D De Carvalho; Shikhar Sharma; Jueng Soo You; Sheng-Fang Su; Phillippa C Taberlay; Theresa K Kelly; Xiaojing Yang; Gangning Liang; Peter A Jones
Journal:  Cancer Cell       Date:  2012-05-15       Impact factor: 31.743

Review 3.  Erase and Rewind: Epigenetic Conversion of Cell Fate.

Authors:  Georgia Pennarossa; Alessandro Zenobi; Cecilia E Gandolfi; Elena F M Manzoni; Fulvio Gandolfi; Tiziana A L Brevini
Journal:  Stem Cell Rev Rep       Date:  2016-04       Impact factor: 5.739

4.  Global DNA methylation remodeling accompanies CD8 T cell effector function.

Authors:  Christopher D Scharer; Benjamin G Barwick; Benjamin A Youngblood; Rafi Ahmed; Jeremy M Boss
Journal:  J Immunol       Date:  2013-08-16       Impact factor: 5.422

Review 5.  Epigenetic choreography of stem cells: the DNA demethylation episode of development.

Authors:  Swayamsiddha Kar; Sabnam Parbin; Moonmoon Deb; Arunima Shilpi; Dipta Sengupta; Sandip Kumar Rath; Madhumita Rakshit; Aditi Patra; Samir Kumar Patra
Journal:  Cell Mol Life Sci       Date:  2013-10-10       Impact factor: 9.261

6.  OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes.

Authors:  Jueng Soo You; Theresa K Kelly; Daniel D De Carvalho; Phillippa C Taberlay; Gangning Liang; Peter A Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-15       Impact factor: 11.205

Review 7.  Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier.

Authors:  Akira Watanabe; Yasuhiro Yamada; Shinya Yamanaka
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-01-05       Impact factor: 6.237

8.  AID and TET2 co-operation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma.

Authors:  J Jiao; Y Jin; M Zheng; H Zhang; M Yuan; Z Lv; W Odhiambo; X Yu; P Zhang; C Li; Y Ma; Y Ji
Journal:  Clin Exp Immunol       Date:  2018-11-13       Impact factor: 4.330

Review 9.  Epigenetic Determinants of Cancer.

Authors:  Stephen B Baylin; Peter A Jones
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-09-01       Impact factor: 10.005

Review 10.  Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition.

Authors:  Sharmila Shankar; Dhruv Kumar; Rakesh K Srivastava
Journal:  Pharmacol Ther       Date:  2012-11-16       Impact factor: 12.310
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