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Literature DB >> 20810265

Mechanisms of aneuploidy.

Abstract

Accurate chromosome segregation during cell division is essential for genome integrity. Errors in chromosome segregation are irreversible and lead to a state of aneuploidy where the number of chromosomes in a cell or organism is not a multiple of the haploid number of chromosomes. Aneuploidy reduces fecundity and is a frequent cause of inherited birth defects. In addition, aneuploidy is very common in solid tumors where it is associated with poor patient prognosis. Recent work has revealed the most common pathways by which chromosomes mis-segregate leading to aneuploidy. Moreover, answers to the key question of how cells respond to aneuploidy are beginning to emerge.

Entities: Disease Gene Species

Mesh：

Year: 2011 PMID： 20810265 PMCID： PMC2997176 DOI： 10.1016/j.ceb.2010.08.007

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

32 in total

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Journal: Mutagenesis Date: 1999-11 Impact factor: 3.000

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Journal: Proc Natl Acad Sci U S A Date: 2001-11-06 Impact factor: 11.205

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Journal: Nat Rev Cancer Date: 2002-11 Impact factor: 60.716

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Authors: Daniela Cimini; Ben Moree; Julie C Canman; E D Salmon
Journal: J Cell Sci Date: 2003-09-02 Impact factor: 5.285

5. Spindle multipolarity is prevented by centrosomal clustering.

Authors: Nicholas J Quintyne; Janet E Reing; Diane R Hoffelder; Susanne M Gollin; William S Saunders
Journal: Science Date: 2005-01-07 Impact factor: 47.728

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Journal: Nature Date: 1997-04-10 Impact factor: 49.962

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Journal: Nature Date: 1998-03-19 Impact factor: 49.962

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Authors: Stevens K Rehen; Yun C Yung; Matthew P McCreight; Dhruv Kaushal; Amy H Yang; Beatriz S V Almeida; Marcy A Kingsbury; Kátia M S Cabral; Michael J McConnell; Brigitte Anliker; Marisa Fontanoz; Jerold Chun
Journal: J Neurosci Date: 2005-03-02 Impact factor: 6.167

9. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells.

Authors: D Cimini; B Howell; P Maddox; A Khodjakov; F Degrassi; E D Salmon
Journal: J Cell Biol Date: 2001-04-30 Impact factor: 10.539

10. A mechanism linking extra centrosomes to chromosomal instability.

Authors: Neil J Ganem; Susana A Godinho; David Pellman
Journal: Nature Date: 2009-06-07 Impact factor: 49.962

38 in total

1. Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast.

Authors: Tessie M Ng; Tineke L Lenstra; Nicole Duggan; Shuangying Jiang; Steven Ceto; Frank C P Holstege; Junbiao Dai; Jef D Boeke; Sue Biggins
Journal: Genetics Date: 2013-09-13 Impact factor: 4.562

2. Using Photobleaching to Measure Spindle Microtubule Dynamics in Primary Cultures of Dividing Drosophila Meiotic Spermatocytes.

Authors: Matthew S Savoian
Journal: J Biomol Tech Date: 2015-07

Review 3. Causes and consequences of aneuploidy in cancer.

Authors: David J Gordon; Benjamin Resio; David Pellman
Journal: Nat Rev Genet Date: 2012-01-24 Impact factor: 53.242

Review 4. Genome Stability Requires p53.

Authors: Christine M Eischen
Journal: Cold Spring Harb Perspect Med Date: 2016-06-01 Impact factor: 6.915

5. Analysis of tubulin alpha-1A/1B C-terminal tail post-translational poly-glutamylation reveals novel modification sites.

Authors: Ziad J Sahab; Alexander Kirilyuk; Lihua Zhang; Zahraa I Khamis; Petr Pompach; Youme Sung; Stephen W Byers
Journal: J Proteome Res Date: 2012-02-15 Impact factor: 4.466