| Literature DB >> 20805031 |
Craig Jamieson1, Stephanie Basten, Robert A Campbell, Iain A Cumming, Kevin J Gillen, Jonathan Gillespie, Bert Kazemier, Michael Kiczun, Yvonne Lamont, Amanda J Lyons, John K F Maclean, Elizabeth M Moir, John A Morrow, Marianthi Papakosta, Zoran Rankovic, Lynn Smith.
Abstract
Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22, a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor.Mesh：
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Year: 2010 PMID： 20805031 DOI： 10.1016/j.bmcl.2010.07.138
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823