Literature DB >> 20804967

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.

Martin Sauvageau1, Guy Sauvageau.   

Abstract

Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify chromatin and participate in the establishment and maintenance of cell fates. These proteins play important roles in both stem cell self-renewal and in cancer development. Our understanding of their mechanism of action has greatly advanced over the past 10 years, but many unanswered questions remain. In this review, we present the currently available experimental data that connect PcG protein function with some of the key processes which govern somatic stem cell activity. We also highlight recent studies suggesting that a delicate balance in PcG gene dosage is crucial for proper stem cell homeostasis and prevention of cancer stem cell development. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20804967      PMCID： PMC4959883          DOI： 10.1016/j.stem.2010.08.002

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  189 in total

1.  The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.

Authors:  Giuseppina Caretti; Monica Di Padova; Bruce Micales; Gary E Lyons; Vittorio Sartorelli
Journal:  Genes Dev       Date:  2004-11-01       Impact factor: 11.361

2.  Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites.

Authors:  Qianzheng Zhu; Gulzar Wani; Hany H Arab; Mohamed A El-Mahdy; Alo Ray; Altaf A Wani
Journal:  DNA Repair (Amst)       Date:  2008-12-20

3.  Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells.

Authors:  Yohei Shimono; Maider Zabala; Robert W Cho; Neethan Lobo; Piero Dalerba; Dalong Qian; Maximilian Diehn; Huiping Liu; Sarita P Panula; Eric Chiao; Frederick M Dirbas; George Somlo; Renee A Reijo Pera; Kaiqin Lao; Michael F Clarke
Journal:  Cell       Date:  2009-08-07       Impact factor: 41.582

4.  DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

Authors:  Steven Bergink; Florian A Salomons; Deborah Hoogstraten; Tom A M Groothuis; Harm de Waard; Junxin Wu; Li Yuan; Elisabetta Citterio; Adriaan B Houtsmuller; Jacques Neefjes; Jan H J Hoeijmakers; Wim Vermeulen; Nico P Dantuma
Journal:  Genes Dev       Date:  2006-05-15       Impact factor: 11.361

5.  Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.

Authors:  Helai P Mohammad; Yi Cai; Kelly M McGarvey; Hariharan Easwaran; Leander Van Neste; Joyce E Ohm; Heather M O'Hagan; Stephen B Baylin
Journal:  Cancer Res       Date:  2009-07-14       Impact factor: 12.701

6.  Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A.

Authors:  Tiziana Tonini; Luigi Bagella; Giuseppina D'Andrilli; Pier Paolo Claudio; Antonio Giordano
Journal:  Oncogene       Date:  2004-06-17       Impact factor: 9.867

7.  SUMO-dependent regulation of centrin-2.

Authors:  Ulf R Klein; Erich A Nigg
Journal:  J Cell Sci       Date:  2009-08-25       Impact factor: 5.285

8.  Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.

Authors:  Véronique Gelsi-Boyer; Virginie Trouplin; José Adélaïde; Julien Bonansea; Nathalie Cervera; Nadine Carbuccia; Arnaud Lagarde; Thomas Prebet; Meyer Nezri; Danielle Sainty; Sylviane Olschwang; Luc Xerri; Max Chaffanet; Marie-Joëlle Mozziconacci; Norbert Vey; Daniel Birnbaum
Journal:  Br J Haematol       Date:  2009-04-15       Impact factor: 6.998

9.  A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche.

Authors:  Yoon-Young Jang; Saul J Sharkis
Journal:  Blood       Date:  2007-06-26       Impact factor: 22.113

10.  Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells.

Authors:  Julie K Stock; Sara Giadrossi; Miguel Casanova; Emily Brookes; Miguel Vidal; Haruhiko Koseki; Neil Brockdorff; Amanda G Fisher; Ana Pombo
Journal:  Nat Cell Biol       Date:  2007-11-25       Impact factor: 28.824
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  322 in total

1.  Epigenetics and mutations in chronic myeloproliferative neoplasms.

Authors:  Alessandro M Vannucchi; Flavia Biamonte
Journal:  Haematologica       Date:  2011-10       Impact factor: 9.941

2.  Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage.

Authors:  Eunjeong Seo; Upal Basu-Roy; Jiri Zavadil; Claudio Basilico; Alka Mansukhani
Journal:  Mol Cell Biol       Date:  2011-09-19       Impact factor: 4.272

3.  The PCL1-p53 axis promotes cellular quiescence.

Authors:  Gerard L Brien; Adrian P Bracken
Journal:  Cell Cycle       Date:  2015-12-10       Impact factor: 4.534

4.  Rottlerin inhibits cell growth and invasion via down-regulation of EZH2 in prostate cancer.

Authors:  Nana Zheng; Lixia Wang; Yingying Hou; Xiuxia Zhou; Youhua He; Zhiwei Wang
Journal:  Cell Cycle       Date:  2018-11-15       Impact factor: 4.534

5.  Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2.

Authors:  Meilan He; Wei Zhang; Thomas Bakken; Melissa Schutten; Zsolt Toth; Jae U Jung; Parkash Gill; Mark Cannon; Shou-Jiang Gao
Journal:  Cancer Res       Date:  2012-05-16       Impact factor: 12.701

6.  PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.

Authors:  Idan Cohen; Dejian Zhao; Carmit Bar; Victor J Valdes; Katherine L Dauber-Decker; Minh Binh Nguyen; Manabu Nakayama; Michael Rendl; Wendy A Bickmore; Haruhiko Koseki; Deyou Zheng; Elena Ezhkova
Journal:  Cell Stem Cell       Date:  2018-05-03       Impact factor: 24.633

Review 7.  EZH2: not EZHY (easy) to deal.

Authors:  Gauri Deb; Anup Kumar Singh; Sanjay Gupta
Journal:  Mol Cancer Res       Date:  2014-02-13       Impact factor: 5.852

Review 8.  Cellular mechanisms of somatic stem cell aging.

Authors:  Yunjoon Jung; Andrew S Brack
Journal:  Curr Top Dev Biol       Date:  2014       Impact factor: 4.897

9.  FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma.

Authors:  L Sehgal; R Mathur; F K Braun; J F Wise; Z Berkova; S Neelapu; L W Kwak; F Samaniego
Journal:  Leukemia       Date:  2014-04-03       Impact factor: 11.528

10.  Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells.

Authors:  Yannick D Benoit; Mavee S Witherspoon; Kristian B Laursen; Amel Guezguez; Marco Beauséjour; Jean-Francois Beaulieu; Steven M Lipkin; Lorraine J Gudas
Journal:  Exp Cell Res       Date:  2013-04-12       Impact factor: 3.905
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