Literature DB >> 20804202

Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.

Fraser F Fleming1, Lihua Yao, P C Ravikumar, Lee Funk, Brian C Shook.   

Abstract

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Year:  2010        PMID： 20804202      PMCID： PMC2988972          DOI： 10.1021/jm100762r

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  217 in total

1.  Comparative investigations of genotoxic activity of five nitriles in the comet assay and the Ames test.

Authors:  Jong-C Wu; You C Hseu; Chin-H Chen; Shu-H Wang; Ssu C Chen
Journal:  J Hazard Mater       Date:  2009-04-02       Impact factor: 10.588

2.  Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in healthy male subjects.

Authors:  Xiao-Jian Zhou; R Colin Garner; Sheila Nicholson; C James Kissling; Douglas Mayers
Journal:  J Clin Pharmacol       Date:  2009-09-23       Impact factor: 3.126

Review 3.  New antiretroviral drugs: a review of the efficacy, safety, pharmacokinetics, and resistance profile of tipranavir, darunavir, etravirine, rilpivirine, maraviroc, and raltegravir.

Authors:  Christine A Hughes; Linda Robinson; Alice Tseng; Rodger D MacArthur
Journal:  Expert Opin Pharmacother       Date:  2009-10       Impact factor: 3.889

4.  Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer.

Authors:  Harold J Burstein; Yan Sun; Luc Y Dirix; Zefei Jiang; Robert Paridaens; Antoinette R Tan; Ahmad Awada; Anantbhushan Ranade; Shunchang Jiao; Gary Schwartz; Richat Abbas; Christine Powell; Kathleen Turnbull; Jennifer Vermette; Charles Zacharchuk; Rajendra Badwe
Journal:  J Clin Oncol       Date:  2010-02-08       Impact factor: 44.544

Review 5.  Cimetidine, an unexpected anti-tumor agent, and its potential for the treatment of glioblastoma (review).

Authors:  Florence Lefranc; Paul Yeaton; Jacques Brotchi; Robert Kiss
Journal:  Int J Oncol       Date:  2006-05       Impact factor: 5.650

6.  Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors.

Authors:  Charles Erlichman; Manuel Hidalgo; Joseph P Boni; Patricia Martins; Susan E Quinn; Charles Zacharchuk; Peter Amorusi; Alex A Adjei; Eric K Rowinsky
Journal:  J Clin Oncol       Date:  2006-05-20       Impact factor: 44.544

7.  Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.

Authors:  Andrew Fensome; Reinhold Bender; Rajiv Chopra; Jeff Cohen; Mark A Collins; Valerie Hudak; Karl Malakian; Susan Lockhead; Andrea Olland; Kristine Svenson; Eugene A Terefenko; Ray J Unwalla; James M Wilhelm; Scott Wolfrom; Yuan Zhu; Zhiming Zhang; Puwen Zhang; Richard C Winneker; Jay Wrobel
Journal:  J Med Chem       Date:  2005-08-11       Impact factor: 7.446

Review 8.  Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.

Authors:  Carolyn F Deacon; Jens J Holst
Journal:  Adv Ther       Date:  2009-05-14       Impact factor: 3.845

Review 9.  Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression.

Authors:  Arif Khan
Journal:  Expert Opin Investig Drugs       Date:  2009-11       Impact factor: 6.206

10.  Alogliptin: a new addition to the class of DPP-4 inhibitors.

Authors:  Radha Andukuri; Andjela Drincic; Marc Rendell
Journal:  Diabetes Metab Syndr Obes       Date:  2009-07-21       Impact factor: 3.168
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  129 in total

1.  Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Authors:  Anthony V Pensa; Maris A Cinelli; Huiying Li; Georges Chreifi; Paramita Mukherjee; Linda J Roman; Pavel Martásek; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2017-08-04       Impact factor: 7.446

2.  η 2 Coordination of Electron-Deficient Arenes with Group 6 Dearomatization Agents.

Authors:  Jacob A Smith; Spenser R Simpson; Karl S Westendorff; Justin Weatherford-Pratt; Jeffery T Myers; Justin H Wilde; Diane A Dickie; W Dean Harman
Journal:  Organometallics       Date:  2020-06-25       Impact factor: 3.876

3.  Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles.

Authors:  Karan Arora; Jessica K White; Rajgopal Sharma; Shivnath Mazumder; Philip D Martin; H Bernhard Schlegel; Claudia Turro; Jeremy J Kodanko
Journal:  Inorg Chem       Date:  2016-06-29       Impact factor: 5.165

4.  Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.

Authors:  Krisztina M Papp-Wallace; Nhu Q Nguyen; Michael R Jacobs; Christopher R Bethel; Melissa D Barnes; Vijay Kumar; Saralee Bajaksouzian; Susan D Rudin; Philip N Rather; Satish Bhavsar; Tadiparthi Ravikumar; Prasad K Deshpande; Vijay Patil; Ravindra Yeole; Sachin S Bhagwat; Mahesh V Patel; Focco van den Akker; Robert A Bonomo
Journal:  J Med Chem       Date:  2018-04-20       Impact factor: 7.446

5.  Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.

Authors:  Eamon Comer; Haibo Liu; Adrien Joliton; Alexandre Clabaut; Christopher Johnson; Lakshmi B Akella; Lisa A Marcaurelle
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

6.  Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes.

Authors:  Hong Geun Lee; Phillip J Milner; Michael S Placzek; Stephen L Buchwald; Jacob M Hooker
Journal:  J Am Chem Soc       Date:  2015-01-09       Impact factor: 15.419

7.  Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors.

Authors:  Dhimant Desai; Matthew Lauver; Alexandria Ostman; Linda Cruz; Kevin Ferguson; Ge Jin; Brianne Roper; Daniel Brosius; Aron Lukacher; Shantu Amin; Nick Buchkovich
Journal:  Bioorg Med Chem       Date:  2019-03-13       Impact factor: 3.641

8.  Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands.

Authors:  Yi Zheng; Samuel Obeng; Huiqun Wang; Abdulmajeed M Jali; Bharath Peddibhotla; Dwight A Williams; Chuanchun Zou; David L Stevens; William L Dewey; Hamid I Akbarali; Dana E Selley; Yan Zhang
Journal:  J Med Chem       Date:  2019-01-11       Impact factor: 7.446

9.  Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.

Authors:  John H Hutchinson; Martin W Rowbottom; David Lonergan; Janice Darlington; Pat Prodanovich; Christopher D King; Jilly F Evans; Gretchen Bain
Journal:  ACS Med Chem Lett       Date:  2017-03-01       Impact factor: 4.345

10.  Acetonitrile Ion Suppression in Atmospheric Pressure Ionization Mass Spectrometry.

Authors:  Kevin Colizza; Keira E Mahoney; Alexander V Yevdokimov; James L Smith; Jimmie C Oxley
Journal:  J Am Soc Mass Spectrom       Date:  2016-08-30       Impact factor: 3.109
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