Literature DB >> 25565277

Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes.

Hong Geun Lee1, Phillip J Milner, Michael S Placzek, Stephen L Buchwald, Jacob M Hooker.   

Abstract

A new radiosynthetic protocol for the preparation of [(11)C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [(11)C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [(11)C]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency.

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Year:  2015        PMID： 25565277      PMCID： PMC4394387          DOI： 10.1021/ja512115s

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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10.  Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes.

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