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Literature DB >> 20804174

Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.

Yegor Smurnyy, Angela V Toms, Gilles R Hickson, Michael J Eck, Ulrike S Eggert.

Abstract

Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binucleine 2 is a highly isoform-specific inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificity for Aurora B. Using Binucleine 2, we show that Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2010 PMID： 20804174 PMCID： PMC3039078 DOI： 10.1021/cb1001685

Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100

23 in total

1. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.

Authors: Ryoma Ohi; Tanuj Sapra; Jonathan Howard; Timothy J Mitchison
Journal: Mol Biol Cell Date: 2004-04-02 Impact factor: 4.138

Review 2. Aurora-A - a guardian of poles.

Authors: Tomotoshi Marumoto; Dongwei Zhang; Hideyuki Saya
Journal: Nat Rev Cancer Date: 2005-01 Impact factor: 60.716

3. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles.

Authors: D M Glover; M H Leibowitz; D A McLean; H Parry
Journal: Cell Date: 1995-04-07 Impact factor: 41.582

4. Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.

Authors: Fabio Sessa; Marina Mapelli; Claudio Ciferri; Cataldo Tarricone; Liliana B Areces; Thomas R Schneider; P Todd Stukenberg; Andrea Musacchio
Journal: Mol Cell Date: 2005-04-29 Impact factor: 17.970

5. Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis.

Authors: Annika Guse; Masanori Mishima; Michael Glotzer
Journal: Curr Biol Date: 2005-04-26 Impact factor: 10.834

6. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance.

Authors: Susan Branford; Zbigniew Rudzki; Sonya Walsh; Andrew Grigg; Chris Arthur; Kerry Taylor; Richard Herrmann; Kevin P Lynch; Timothy P Hughes
Journal: Blood Date: 2002-05-01 Impact factor: 22.113

7. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

Authors: C E Sunkel; D M Glover
Journal: J Cell Sci Date: 1988-01 Impact factor: 5.285

8. INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization.

Authors: Zhenjie Xu; Hiromi Ogawa; Paola Vagnarelli; Jan H Bergmann; Damien F Hudson; Sandrine Ruchaud; Tatsuo Fukagawa; William C Earnshaw; Kumiko Samejima
Journal: J Cell Biol Date: 2009-11-30 Impact factor: 10.539

9. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo.

Authors: Elizabeth A Harrington; David Bebbington; Jeff Moore; Richele K Rasmussen; Abi O Ajose-Adeogun; Tomoko Nakayama; Joanne A Graham; Cecile Demur; Thierry Hercend; Anita Diu-Hercend; Michael Su; Julian M C Golec; Karen M Miller
Journal: Nat Med Date: 2004-02-22 Impact factor: 53.440

7. Micronuclei Formation Is Prevented by Aurora B-Mediated Exclusion of HP1a from Late-Segregating Chromatin in Drosophila.

Authors: Brandt Warecki; William Sullivan
Journal: Genetics Date: 2018-07-09 Impact factor: 4.562

Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.

1. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.

Review 2. Aurora-A - a guardian of poles.

3. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles.

4. Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.

5. Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis.

6. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance.

7. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

8. INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization.

9. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo.

10. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.

1. Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells.

2. Aurora A Kinase Amplifies a Midzone Phosphorylation Gradient to Promote High-Fidelity Cytokinesis.

Review 3. Generating and working with Drosophila cell cultures: Current challenges and opportunities.

4. Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.

5. Techniques for Imaging Prometaphase and Metaphase of Meiosis I in Fixed Drosophila Oocytes.

6. Feedback control of chromosome separation by a midzone Aurora B gradient.

7. Micronuclei Formation Is Prevented by Aurora B-Mediated Exclusion of HP1a from Late-Segregating Chromatin in Drosophila.

8. Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis.

9. Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.

10. Ulrike Eggert: big things from small molecules. Interview by Caitlin Sedwick.