Literature DB >> 15630414

Aurora-A - a guardian of poles.

Tomotoshi Marumoto1, Dongwei Zhang, Hideyuki Saya.   

Abstract

The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15630414     DOI： 10.1038/nrc1526

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  268 in total

1.  Additive effects of vorinostat and MLN8237 in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines.

Authors:  Jodi A Muscal; Kathleen A Scorsone; Linna Zhang; Jeffrey A Ecsedy; Stacey L Berg
Journal:  Invest New Drugs       Date:  2012-06-06       Impact factor: 3.850

2.  Alisertib (MLN8237), a selective Aurora-A kinase inhibitor, induces apoptosis in human tongue squamous cell carcinoma cell both in vitro and in vivo.

Authors:  Lin Qi; Yang Zhang
Journal:  Tumour Biol       Date:  2014-11-04

3.  Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53.

Authors:  Lorna Jane Warnock; Sally Anne Raines; Jo Milner
Journal:  Cancer Biol Ther       Date:  2011-12-15       Impact factor: 4.742

4.  Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma.

Authors:  Daruka Mahadevan; Amy Stejskal; Laurence S Cooke; Ann Manziello; Carla Morales; Daniel O Persky; Richard I Fisher; Thomas P Miller; Wenqing Qi
Journal:  Clin Cancer Res       Date:  2012-02-28       Impact factor: 12.531

5.  Bioorthogonal imaging of aurora kinase A in live cells.

Authors:  Katherine S Yang; Ghyslain Budin; Thomas Reiner; Claudio Vinegoni; Ralph Weissleder
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-29       Impact factor: 15.336

6.  Computational Systems Biology of Psoriasis: Are We Ready for the Age of Omics and Systems Biomarkers?

Authors:  Tuba Sevimoglu; Kazim Yalcin Arga
Journal:  OMICS       Date:  2015-10-19

Review 7.  Centrosomes and cancer: revisiting a long-standing relationship.

Authors:  Pierre Gönczy
Journal:  Nat Rev Cancer       Date:  2015-11       Impact factor: 60.716

Review 8.  Aurora kinases in head and neck cancer.

Authors:  Ranee Mehra; Ilya G Serebriiskii; Barbara Burtness; Igor Astsaturov; Erica A Golemis
Journal:  Lancet Oncol       Date:  2013-09       Impact factor: 41.316

9.  Aurora-A kinase is essential for bipolar spindle formation and early development.

Authors:  Dale O Cowley; Jaime A Rivera-Pérez; Mark Schliekelman; Yizhou Joseph He; Trudy G Oliver; Lucy Lu; Ryan O'Quinn; E D Salmon; Terry Magnuson; Terry Van Dyke
Journal:  Mol Cell Biol       Date:  2008-12-15       Impact factor: 4.272

10.  Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.

Authors:  Su-Yeon Lee; Eun-Young Kim; Kyeoung-Hwa Kim; Kyung-Ah Lee
Journal:  Cell Cycle       Date:  2016-10-18       Impact factor: 4.534
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.