Literature DB >> 20803520

Retinoic acid: a key player in immunity.

Karina Pino-Lagos1, Yanxia Guo, Randolph J Noelle.   

Abstract

For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment.
Copyright © 2010 International Union of Biochemistry and Molecular Biology, Inc.

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Year:  2010        PMID： 20803520      PMCID： PMC3826167          DOI： 10.1002/biof.117

Source DB:  PubMed          Journal:  Biofactors        ISSN： 0951-6433            Impact factor:   6.113


  59 in total

1.  Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.

Authors:  Laurie E Harrington; Robin D Hatton; Paul R Mangan; Henrietta Turner; Theresa L Murphy; Kenneth M Murphy; Casey T Weaver
Journal:  Nat Immunol       Date:  2005-10-02       Impact factor: 25.606

2.  Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency.

Authors:  P V Bhat
Journal:  FEBS Lett       Date:  1998-04-17       Impact factor: 4.124

Review 3.  Retinoic acid: its biosynthesis and metabolism.

Authors:  J L Napoli
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1999

4.  All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients.

Authors:  Noweeda Mirza; Mayer Fishman; Ingo Fricke; Mary Dunn; Anthony M Neuger; Timothy J Frost; Richard M Lush; Scott Antonia; Dmitry I Gabrilovich
Journal:  Cancer Res       Date:  2006-09-15       Impact factor: 12.701

5.  Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance.

Authors:  Charles B Stephensen; Alexander D Borowsky; Kevin C Kent Lloyd
Journal:  Immunology       Date:  2007-04-13       Impact factor: 7.397

6.  Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.

Authors:  S S Abu-Abed; B R Beckett; H Chiba; J V Chithalen; G Jones; D Metzger; P Chambon; M Petkovich
Journal:  J Biol Chem       Date:  1998-01-23       Impact factor: 5.157

7.  Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB.

Authors:  S Y Na; B Y Kang; S W Chung; S J Han; X Ma; G Trinchieri; S Y Im; J W Lee; T S Kim
Journal:  J Biol Chem       Date:  1999-03-19       Impact factor: 5.157

8.  Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages.

Authors:  K Mehta; T McQueen; S Tucker; R Pandita; B B Aggarwal
Journal:  J Leukoc Biol       Date:  1994-03       Impact factor: 4.962

Review 9.  Unusual evolution of 11beta- and 17beta-hydroxysteroid and retinol dehydrogenases.

Authors:  M E Baker
Journal:  Bioessays       Date:  1996-01       Impact factor: 4.345

10.  Dominant negative retinoic acid receptor initiates tumor formation in mice.

Authors:  Tara S Kupumbati; Giorgio Cattoretti; Christine Marzan; Eduardo F Farias; Reshma Taneja; Rafael Mira-y-Lopez
Journal:  Mol Cancer       Date:  2006-03-24       Impact factor: 27.401
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  35 in total

1.  Hepatic vitamin A preloading reduces colorectal cancer metastatic multiplicity in a mouse xenograft model.

Authors:  Eun Young Park; Daniel Pinali; Krista Lindley; Michelle A Lane
Journal:  Nutr Cancer       Date:  2012-05-29       Impact factor: 2.900

2.  Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.

Authors:  Julie Norseen; Tetsuya Hosooka; Ann Hammarstedt; Mark M Yore; Shashi Kant; Pratik Aryal; Urban A Kiernan; David A Phillips; Hiroshi Maruyama; Bettina J Kraus; Anny Usheva; Roger J Davis; Ulf Smith; Barbara B Kahn
Journal:  Mol Cell Biol       Date:  2012-03-19       Impact factor: 4.272

3.  Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.

Authors:  Kristin M Obrochta; Charles R Krois; Benito Campos; Joseph L Napoli
Journal:  J Biol Chem       Date:  2015-01-27       Impact factor: 5.157

4.  [Prophylactic administration of all-trans retinoic acid alleviates inflammation in rats with collagen-induced arthritis].

Authors:  Xiang Zeng; Jing-Yan Shan; Yang Liu; Yan-Hua Ning; Xue-Jian Xie; Yu-Yan Shen; Jie Song; Yun Li
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2016-02-20

5.  Effects of retinoic acid receptor-γ on the Aspergillus fumigatus induced innate immunity response in human corneal epithelial cells.

Authors:  Xiao-Chen Wang; Gui-Qiu Zhao; Jing Lin; Cui Li; Nan Jiang; Jie Zhang
Journal:  Int J Ophthalmol       Date:  2016-12-18       Impact factor: 1.779

6.  A Novel Combination of Docosahexaenoic Acid, All-Trans Retinoic Acid, and 1, 25-Dihydroxyvitamin D3 Reduces T-Bet Gene Expression, Serum Interferon Gamma, and Clinical Scores but Promotes PPARγ Gene Expression in Experimental Autoimmune Encephalomyelitis.

Authors:  Mohammad Reza Shiri-Shahsavar; Abbas Mirshafiee; Karim Parastouei; Abbas Ebrahimi-Kalan; Saeed Yekaninejad; Farid Soleymani; Reza Chahardoli; Ramin Mazaheri Nezhad Fard; Ali Akbar Saboor-Yaraghi
Journal:  J Mol Neurosci       Date:  2016-09-19       Impact factor: 3.444

Review 7.  Retinoid and TGF-β families: crosstalk in development, neoplasia, immunity, and tissue repair.

Authors:  Qihe Xu; Jeffrey B Kopp
Journal:  Semin Nephrol       Date:  2012-05       Impact factor: 5.299

8.  Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming.

Authors:  Preston D Crowell; Jenna M Giafaglione; Takao Hashimoto; Andrew S Goldstein
Journal:  Am J Clin Exp Urol       Date:  2020-08-15

9.  Leishmania donovani reduces the levels of retinoic acid-synthesizing enzymes in infected macrophages and favoring its own survival.

Authors:  Pankaj Verma; Amit Kumar Kureel; Sheetal Saini; Satya Prakash; Smita Kumari; Sarath Kumar Kottarath; Sandeep Kumar Srivastava; Madhusudan Bhat; Amit Kumar Dinda; Chandreshwar Prasad Thakur; Shivesh Sharma; Ambak Kumar Rai
Journal:  Parasitol Res       Date:  2018-10-18       Impact factor: 2.289

10.  Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function.

Authors:  Estela J Jauregui; Debra Mitchell; Traci Topping; Cathryn A Hogarth; Michael D Griswold
Journal:  Development       Date:  2018-07-09       Impact factor: 6.868
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