OBJECTIVE: To identify risk factors associated with Persistent diarrhea (PD) and deaths due to PD. METHODS: This prospective case control study included 60 children with PD (cases) and 60 children (controls) with acute diarrhoea (AD). Detailed history, examination and appropriate investigations were done for all children. Crude Odds ratio was calculated for each risk factor by univariate analysis and adjusted odds ratio was calculated by multivariate logistic regression. RESULTS: Prior antibiotic use, steroid use, anemia, vitamin A deficiency, malnutrition, LRI, UTI, oral candidiasis, and hyponatremia, were statistically significant risk factors by univariate analysis. Prior antibiotic use, vitamin A deficiency, malnutrition and LRI were independently associated with PD by multivariate logistic regression analysis. The risk factors for mortality were stool frequency more than 10 times per day, severe malnutrition, oral candidiasis, hypoalbuminemia and HIV positivity. CONCLUSIONS: The presence of these risk factors should alert the clinician to take appropriate measures, to decrease the mortality.
OBJECTIVE: To identify risk factors associated with Persistent diarrhea (PD) and deaths due to PD. METHODS: This prospective case control study included 60 children with PD (cases) and 60 children (controls) with acute diarrhoea (AD). Detailed history, examination and appropriate investigations were done for all children. Crude Odds ratio was calculated for each risk factor by univariate analysis and adjusted odds ratio was calculated by multivariate logistic regression. RESULTS: Prior antibiotic use, steroid use, anemia, vitamin A deficiency, malnutrition, LRI, UTI, oral candidiasis, and hyponatremia, were statistically significant risk factors by univariate analysis. Prior antibiotic use, vitamin A deficiency, malnutrition and LRI were independently associated with PD by multivariate logistic regression analysis. The risk factors for mortality were stool frequency more than 10 times per day, severe malnutrition, oral candidiasis, hypoalbuminemia and HIV positivity. CONCLUSIONS: The presence of these risk factors should alert the clinician to take appropriate measures, to decrease the mortality.
Authors: Katharine A Schilling; Richard Omore; Gordana Derado; Tracy Ayers; John B Ochieng; Tamer H Farag; Dilruba Nasrin; Sandra Panchalingam; James P Nataro; Karen L Kotloff; Myron M Levine; Joseph Oundo; Michelle B Parsons; Cheryl Bopp; Kayla Laserson; Christine E Stauber; Richard Rothenberg; Robert F Breiman; Ciara E O'Reilly; Eric D Mintz Journal: Am J Trop Med Hyg Date: 2017-07 Impact factor: 2.345
Authors: Lahiru Sandaruwan Galgamuwa; Devika Iddawela; Samath D Dharmaratne; G L S Galgamuwa Journal: BMC Public Health Date: 2017-05-02 Impact factor: 3.295
Authors: Melanie Werner; Jan S Suchodolski; Reinhard K Straubinger; Georg Wolf; Jörg M Steiner; Jonathan A Lidbury; Felix Neuerer; Katrin Hartmann; Stefan Unterer Journal: J Vet Intern Med Date: 2020-04-23 Impact factor: 3.333