OBJECTIVES: Neuropsychiatric disorders and increased suicide rates have been associated with exposure to cholinesterase inhibiting organophosphates. This study examined symptoms of psychological distress, including suicidal ideation, among banana workers in Costa Rica previously exposed to a cholinesterase inhibiting pesticide. METHODS: 78 workers who had received medical attention 1-3 years previously for occupational pesticide poisoning were recruited: 54 had been exposed to organophosphate, 24 to carbamate, and 43 and 35, respectively, had single and multiple poisoning episodes with a cholinesterase inhibitor. Referents were 130 non-poisoned workers randomly selected from company payrolls. Psychological distress symptoms during the month prior to interview were obtained using the Brief Symptom Inventory (BSI), which has a general severity index and nine subscale scores. Differences in abnormal BSI scores (T score≥63) were assessed through multivariate logistic regression for all poisoned and for subcategories of poisoned as compared to non-poisoned workers. RESULTS: Organophosphate poisoned workers reported significantly more symptoms than non-poisoned on all but one symptom dimension. Significant trends of increasing symptoms with increasing number of previous poisonings were seen for somatisation, obsessive-compulsiveness, interpersonal sensitivity, depression and anxiety. Carbamate poisoned workers only had increased scores for somatisation. The ORs for suicidal thoughts were: all poisoned 3.58 (95% CI 1.45 to 8.84); organophosphate poisoned 3.72 (1.41 to 9.81); carbamate poisoned 2.57 (0.73 to 9.81); and 2.65 and 4.98, respectively for 1 and ≥2 poisonings (trend p=0.01). CONCLUSIONS: This cross-sectional study showed a relationship between acute occupational poisoning with organophosphates and psychological distress including suicidal ideation. Stronger designs are needed to address causality.
OBJECTIVES:Neuropsychiatric disorders and increased suicide rates have been associated with exposure to cholinesterase inhibiting organophosphates. This study examined symptoms of psychological distress, including suicidal ideation, among banana workers in Costa Rica previously exposed to a cholinesterase inhibiting pesticide. METHODS: 78 workers who had received medical attention 1-3 years previously for occupational pesticide poisoning were recruited: 54 had been exposed to organophosphate, 24 to carbamate, and 43 and 35, respectively, had single and multiple poisoning episodes with a cholinesterase inhibitor. Referents were 130 non-poisoned workers randomly selected from company payrolls. Psychological distress symptoms during the month prior to interview were obtained using the Brief Symptom Inventory (BSI), which has a general severity index and nine subscale scores. Differences in abnormal BSI scores (T score≥63) were assessed through multivariate logistic regression for all poisoned and for subcategories of poisoned as compared to non-poisoned workers. RESULTS:Organophosphate poisoned workers reported significantly more symptoms than non-poisoned on all but one symptom dimension. Significant trends of increasing symptoms with increasing number of previous poisonings were seen for somatisation, obsessive-compulsiveness, interpersonal sensitivity, depression and anxiety. Carbamate poisoned workers only had increased scores for somatisation. The ORs for suicidal thoughts were: all poisoned 3.58 (95% CI 1.45 to 8.84); organophosphate poisoned 3.72 (1.41 to 9.81); carbamate poisoned 2.57 (0.73 to 9.81); and 2.65 and 4.98, respectively for 1 and ≥2 poisonings (trend p=0.01). CONCLUSIONS: This cross-sectional study showed a relationship between acute occupational poisoning with organophosphates and psychological distress including suicidal ideation. Stronger designs are needed to address causality.
Authors: Jose R Suarez-Lopez; Naomi Hood; José Suárez-Torres; Sheila Gahagan; Megan R Gunnar; Dolores López-Paredes Journal: Int J Hyg Environ Health Date: 2019-06-13 Impact factor: 5.840
Authors: Cristina Paula do Nascimento; Gabriella Xavier Maretto; Graziany Leite Moreira Marques; Luciana Mesquita Passamani; Ana Paula Abdala; Luiz Carlos Schenberg; Vanessa Beijamini; Karla Nívea Sampaio Journal: Neurotox Res Date: 2017-05-24 Impact factor: 3.911
Authors: Dirk Hölscher; Suganthagunthalam Dhakshinamoorthy; Theodore Alexandrov; Michael Becker; Tom Bretschneider; Andreas Buerkert; Anna C Crecelius; Dirk De Waele; Annemie Elsen; David G Heckel; Heike Heklau; Christian Hertweck; Marco Kai; Katrin Knop; Christoph Krafft; Ravi K Maddula; Christian Matthäus; Jürgen Popp; Bernd Schneider; Ulrich S Schubert; Richard A Sikora; Aleš Svatoš; Rony L Swennen Journal: Proc Natl Acad Sci U S A Date: 2013-12-09 Impact factor: 11.205
Authors: John D Beard; Jane A Hoppin; Marie Richards; Michael C R Alavanja; Aaron Blair; Dale P Sandler; Freya Kamel Journal: Environ Res Date: 2013-08-02 Impact factor: 6.498