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Literature DB >> 20795743

Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp.

Megan Sturdy¹, Aleksej Krunic, Sanghyun Cho, Scott Franzblau, Jimmy Orjala.

Abstract

Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by bioassay-guided fractionation. The chemical structure was determined by analyzing MS and 1D and 2D NMR spectroscopic data. Eucapsitrione (1) showed anti-Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 3.1 and 6.4 microM, respectively.

Entities: CellLine Chemical Disease Mutation Species

Mesh：

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Year: 2010 PMID： 20795743 PMCID： PMC2972581 DOI： 10.1021/np100299v

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

11 in total

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4 in total

1. Elucidation of marine fungi derived anthraquinones as mycobacterial mycolic acid synthesis inhibitors: an in silico approach.

Authors: Akanksha Sharma; M Hayatul Islam; Nida Fatima; Tarun K Upadhyay; M Kalim A Khan; Upendra N Dwivedi; Rolee Sharma
Journal: Mol Biol Rep Date: 2019-02-04 Impact factor: 2.316