Literature DB >> 20795674

Phagocytosis of biocompatible gold nanoparticles.

Zeljka Krpetić1, Francesca Porta, Enrico Caneva, Vladimiro Dal Santo, Giorgio Scarì.   

Abstract

We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis mechanism in murine macrophage cells strongly supported by TEM and optical microscopy. Nanoparticles were prepared using several biocompatible molecules of choice (5-aminovaleric acid, l-DOPA, melatonin, and serotonin hydrochloride) as stabilizers for gold colloids. Their surface chemistry was fully characterized by UV-vis, ATR-FTIR, (1)H NMR, and HR-MAS (1)H NMR spectroscopies, and size distribution was determined by CPS disc centrifuge and TEM. Differences in coatings were evaluated against cellular uptake, and a preferential movement of macrophages toward 5-aminovaleric acid-modified gold nanoparticles was shown, leading to the fast accumulation of nanoparticles in the cytosol.

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Year:  2010        PMID： 20795674     DOI： 10.1021/la102758f

Source DB:  PubMed          Journal:  Langmuir        ISSN： 0743-7463            Impact factor:   3.882


  12 in total

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Review 10.  Toxicity of Transition Metal Oxide Nanoparticles: Recent Insights from in vitro Studies.

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