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Literature DB >> 20737293

Glioma stem cells as a target for treatment.

Abstract

Glioma cells with stem cell-like properties represent a minor subfraction of the total tumor cell population. These cells are highly chemo- and radioresistent and are held responsible for the inevitable recurrence of malignant gliomas. This review summarizes current strategies for targeting putative glioma stem cells. Target definition approaches comprise extrapolation and adaptation of therapies from general oncology, target identification by correlative molecular genetic analyses, and dedicated target discovery research. Targeting strategies include inhibition of tumor-specific signaling pathways, enhancement of tumor cell differentiation, radiosensitization, indirect targeting of the tumor stem cell niche, oncolytic virotherapy, and adhesion molecule blockade.

Entities: Disease

Mesh：

Substances：
Antineoplastic Agents

Year: 2010 PMID： 20737293 DOI： 10.1007/s11523-010-0155-4

Source DB: PubMed Journal: Target Oncol ISSN： 1776-2596 Impact factor: 4.493

47 in total

1. Differentiation therapy exerts antitumor effects on stem-like glioma cells.

Authors: Benito Campos; Feng Wan; Mohammad Farhadi; Aurélie Ernst; Felix Zeppernick; Katrin E Tagscherer; Rezvan Ahmadi; Jennifer Lohr; Christine Dictus; Georg Gdynia; Stephanie E Combs; Violaine Goidts; Burkhard M Helmke; Volker Eckstein; Wilfried Roth; Philipp Beckhove; Peter Lichter; Andreas Unterberg; Bernhard Radlwimmer; Christel Herold-Mende
Journal: Clin Cancer Res Date: 2010-05-04 Impact factor: 12.531

2. A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

Authors: Ruihuan Chen; Merry C Nishimura; Stephanie M Bumbaca; Samir Kharbanda; William F Forrest; Ian M Kasman; Joan M Greve; Robert H Soriano; Laurie L Gilmour; Celina Sanchez Rivers; Zora Modrusan; Serban Nacu; Steve Guerrero; Kyle A Edgar; Jeffrey J Wallin; Katrin Lamszus; Manfred Westphal; Susanne Heim; C David James; Scott R VandenBerg; Joseph F Costello; Scott Moorefield; Cynthia J Cowdrey; Michael Prados; Heidi S Phillips
Journal: Cancer Cell Date: 2010-04-13 Impact factor: 31.743

3. Targeting cancer stem cells through L1CAM suppresses glioma growth.

Authors: Shideng Bao; Qiulian Wu; Zhizhong Li; Sith Sathornsumetee; Hui Wang; Roger E McLendon; Anita B Hjelmeland; Jeremy N Rich
Journal: Cancer Res Date: 2008-08-01 Impact factor: 12.701

4. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.

Authors: Heiko Wurdak; Shoutian Zhu; Angelica Romero; Mihaela Lorger; James Watson; Chih-Yuan Chiang; Jay Zhang; Vanita S Natu; Luke L Lairson; John R Walker; Christopher M Trussell; Griffith R Harsh; Hannes Vogel; Brunhilde Felding-Habermann; Anthony P Orth; Loren J Miraglia; Daniel R Rines; Stephen L Skirboll; Peter G Schultz
Journal: Cell Stem Cell Date: 2010-01-08 Impact factor: 24.633

5. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells.

Authors: Jian Wang; Per Ø Sakariassen; Oleg Tsinkalovsky; Heike Immervoll; Stig Ove Bøe; Agnete Svendsen; Lars Prestegarden; Gro Røsland; Frits Thorsen; Linda Stuhr; Anders Molven; Rolf Bjerkvig; Per Ø Enger
Journal: Int J Cancer Date: 2008-02-15 Impact factor: 7.396

6. Targeting A20 decreases glioma stem cell survival and tumor growth.

Authors: Anita B Hjelmeland; Qiulian Wu; Sarah Wickman; Christine Eyler; John Heddleston; Qing Shi; Justin D Lathia; Jennifer Macswords; Jeongwu Lee; Roger E McLendon; Jeremy N Rich
Journal: PLoS Biol Date: 2010-02-23 Impact factor: 8.029

7. EZH2 is essential for glioblastoma cancer stem cell maintenance.

Authors: Mario-Luca Suvà; Nicolò Riggi; Michalina Janiszewska; Ivan Radovanovic; Paolo Provero; Jean-Christophe Stehle; Karine Baumer; Marie-Aude Le Bitoux; Denis Marino; Luisa Cironi; Victor E Marquez; Virginie Clément; Ivan Stamenkovic
Journal: Cancer Res Date: 2009-12-15 Impact factor: 12.701

8. Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors.

Authors: Hiroaki Wakimoto; Santosh Kesari; Christopher J Farrell; William T Curry; Cecile Zaupa; Manish Aghi; Toshihiko Kuroda; Anat Stemmer-Rachamimov; Khalid Shah; Ta-Chiang Liu; Deva S Jeyaretna; Jason Debasitis; Jan Pruszak; Robert L Martuza; Samuel D Rabkin
Journal: Cancer Res Date: 2009-04-07 Impact factor: 12.701

Glioma stem cells as a target for treatment.

1. Differentiation therapy exerts antitumor effects on stem-like glioma cells.

2. A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

3. Targeting cancer stem cells through L1CAM suppresses glioma growth.

4. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.

5. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells.

6. Targeting A20 decreases glioma stem cell survival and tumor growth.

7. EZH2 is essential for glioblastoma cancer stem cell maintenance.

8. Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors.

9. Influence of oxygen tension on CD133 phenotype in human glioma cell cultures.

10. Tumor growth need not be driven by rare cancer stem cells.

1. A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells.

2. Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo.

Review 3. Cancer-initiating enriched cell lines from human glioblastoma: preparing for drug discovery assays.

Review 4. EGFR Amplification and Glioblastoma Stem-Like Cells.

5. RNAi for contactin 2 inhibits proliferation of U87-glioma stem cells by downregulating AICD, EGFR, and HES1.

6. TRAIL and paclitaxel synergize to kill U87 cells and U87-derived stem-like cells in vitro.