BACKGROUND: This study investigates how T(1)-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. METHODS: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. RESULTS: The T(1)- and T(2)-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. CONCLUSION: The T(1)-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.
BACKGROUND: This study investigates how T(1)-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. METHODS: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. RESULTS: The T(1)- and T(2)-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. CONCLUSION: The T(1)-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.
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Authors: Michael W Weiner; Dallas P Veitch; Paul S Aisen; Laurel A Beckett; Nigel J Cairns; Robert C Green; Danielle Harvey; Clifford R Jack; William Jagust; Enchi Liu; John C Morris; Ronald C Petersen; Andrew J Saykin; Mark E Schmidt; Leslie Shaw; Li Shen; Judith A Siuciak; Holly Soares; Arthur W Toga; John Q Trojanowski Journal: Alzheimers Dement Date: 2013-08-07 Impact factor: 21.566