BACKGROUND: The reasons for gender disparities in stroke outcome remain unclear, and little is known about the value of acute neuroimaging characteristics in elucidating differential stroke outcomes between the sexes. METHODS: We prospectively evaluated consecutive patients with acute ischemic stroke. CT angiography (CTA) was performed in all patients within 24 h of symptom onset. CTA source images were used to evaluate lesion volume. The primary outcome measure was a modified Rankin scale (mRS) score ≥ 3 at 6 months. RESULTS: We evaluated 676 consecutive patients (322 women). Women were older than men (p < 0.01), more frequently had a prestroke mRS >0 (p < 0.01), and had higher admission National Institutes of Health Stroke scale scores (p = 0.01). More women had intracranial artery occlusions than men (46 vs. 33.1%, p = 0.01), but there was no significant difference between ischemic lesion volumes (p = 0.21). Using multiple regression, female gender remained an independent predictor of poor mRS scores at 6 months (odds ratio 1.57; 95% confidence interval 1.02-2.36) after adjustment for clinical and imaging covariates. CONCLUSION: Compared with men, women are less likely to achieve independence after acute ischemic stroke. The disparity in stroke outcome is not explained by differences in ischemic lesion volume or the presence of intracranial artery occlusions.
BACKGROUND: The reasons for gender disparities in stroke outcome remain unclear, and little is known about the value of acute neuroimaging characteristics in elucidating differential stroke outcomes between the sexes. METHODS: We prospectively evaluated consecutive patients with acute ischemic stroke. CT angiography (CTA) was performed in all patients within 24 h of symptom onset. CTA source images were used to evaluate lesion volume. The primary outcome measure was a modified Rankin scale (mRS) score ≥ 3 at 6 months. RESULTS: We evaluated 676 consecutive patients (322 women). Women were older than men (p < 0.01), more frequently had a prestroke mRS >0 (p < 0.01), and had higher admission National Institutes of Health Stroke scale scores (p = 0.01). More women had intracranial artery occlusions than men (46 vs. 33.1%, p = 0.01), but there was no significant difference between ischemic lesion volumes (p = 0.21). Using multiple regression, female gender remained an independent predictor of poor mRS scores at 6 months (odds ratio 1.57; 95% confidence interval 1.02-2.36) after adjustment for clinical and imaging covariates. CONCLUSION: Compared with men, women are less likely to achieve independence after acute ischemic stroke. The disparity in stroke outcome is not explained by differences in ischemic lesion volume or the presence of intracranial artery occlusions.
Authors: Hong Li; Scott Pin; Zhiyuan Zeng; Michael M Wang; Katrin A Andreasson; Louise D McCullough Journal: Ann Neurol Date: 2005-08 Impact factor: 10.422
Authors: Moira K Kapral; Jiming Fang; Michael D Hill; Frank Silver; Janice Richards; Cheryl Jaigobin; Angela M Cheung Journal: Stroke Date: 2005-02-24 Impact factor: 7.914
Authors: Cheryl D Bushnell; Patricia Hurn; Carol Colton; Virginia M Miller; Gregory del Zoppo; Mitchell S V Elkind; Barney Stern; David Herrington; Gwendolyn Ford-Lynch; Philip Gorelick; Andra James; Candice M Brown; Emily Choi; Paul Bray; L Kristin Newby; Larry B Goldstein; James Simpkins Journal: Stroke Date: 2006-07-20 Impact factor: 7.914
Authors: H P Adams; P H Davis; E C Leira; K C Chang; B H Bendixen; W R Clarke; R F Woolson; M D Hansen Journal: Neurology Date: 1999-07-13 Impact factor: 9.910
Authors: Maciej Niewada; Adam Kobayashi; Peter A G Sandercock; Bogumił Kamiński; Anna Członkowska Journal: Neuroepidemiology Date: 2004-12-30 Impact factor: 3.282
Authors: K O Lövblad; A E Baird; G Schlaug; A Benfield; B Siewert; B Voetsch; A Connor; C Burzynski; R R Edelman; S Warach Journal: Ann Neurol Date: 1997-08 Impact factor: 10.422
Authors: Michael D Hill; David M Kent; Judith Hinchey; Howard Rowley; Alastair M Buchan; Lawrence R Wechsler; Randall T Higashida; Nancy J Fischbein; William P Dillon; Michael Gent; Carolyn M Firszt; Gregory A Schulz; Anthony J Furlan Journal: Stroke Date: 2006-08-03 Impact factor: 7.914
Authors: Yingfang Tian; Boryana Stamova; Glen C Jickling; Dazhi Liu; Bradley P Ander; Cheryl Bushnell; Xinhua Zhan; Ryan R Davis; Piero Verro; William C Pevec; Nasim Hedayati; David L Dawson; Jane Khoury; Edward C Jauch; Arthur Pancioli; Joseph P Broderick; Frank R Sharp Journal: J Cereb Blood Flow Metab Date: 2011-12-14 Impact factor: 6.200
Authors: Yingfang Tian; Boryana Stamova; Glen C Jickling; Huichun Xu; Dazhi Liu; Bradley P Ander; Cheryl Bushnell; Xinhua Zhan; Renee J Turner; Ryan R Davis; Piero Verro; William C Pevec; Nasim Hedayati; David L Dawson; Jane Khoury; Edward C Jauch; Arthur Pancioli; Joseph P Broderick; Frank R Sharp Journal: Gend Med Date: 2012-02-24
Authors: Natalia S Rost; Alessandro Biffi; Lisa Cloonan; John Chorba; Peter Kelly; David Greer; Patrick Ellinor; Karen L Furie Journal: Stroke Date: 2011-11-23 Impact factor: 7.914
Authors: Sunil A Sheth; Songmi Lee; Steven J Warach; Jan Gralla; Reza Jahan; Mayank Goyal; Raul G Nogueira; Osama O Zaidat; Vitor M Pereira; Adnan Siddiqui; Helmi Lutsep; David S Liebeskind; Louise D McCullough; Jeffrey L Saver Journal: Stroke Date: 2019-08-15 Impact factor: 7.914
Authors: Amelia K Boehme; James E Siegler; Michael T Mullen; Karen C Albright; Michael J Lyerly; Dominique J Monlezun; Erica M Jones; Rikki Tanner; Nicole R Gonzales; T Mark Beasley; James C Grotta; Sean I Savitz; Sheryl Martin-Schild Journal: J Stroke Cerebrovasc Dis Date: 2014-01-25 Impact factor: 2.136