Literature DB >> 20732646

Embracing novel cytokines in RA - complexity grows as does opportunity!

Axel J Hueber1, Darren L Asquith, Iain B McInnes, Ashley M Miller.   

Abstract

Current therapeutics for the treatment of rheumatoid arthritis (RA) offer limited efficacy in a restricted number of patients. There is, therefore, an unmet clinical need for the development of more efficacious therapeutics for the treatment of disease. Anti-TNFalpha therapy has provided proof of principle that cytokine blockade is an appropriate strategy by which to inhibit disease progression. In this review, we describe the basic biology of potential novel cytokine targets and the results of recent clinical trials, with particular focus on the cytokines related to Th17 biology, namely interleukin (IL)-12, IL-23 and IL-17, in addition to the TNF superfamily and the adipocytokines. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20732646     DOI： 10.1016/j.berh.2010.01.004

Source DB:  PubMed          Journal:  Best Pract Res Clin Rheumatol        ISSN： 1521-6942            Impact factor:   4.098


  7 in total

1.  Association between IL-33 and other inflammatory factors in patients with rheumatoid arthritis and in fibroblast-like synoviocytes in vitro.

Authors:  Jing Wu; Qiang Li; Jiaxin Deng; Jin-Jun Zhao; Qing-Hong Yu
Journal:  Exp Ther Med       Date:  2020-12-18       Impact factor: 2.447

Review 2.  Adiponectin: a therapeutic target in the antiphospholipid syndrome?

Authors:  Mirjana B Bećarević; Božana S Nikolić; Svetlana D Ignjatović
Journal:  Rheumatol Int       Date:  2019-06-18       Impact factor: 2.631

3.  Colony-Specific Differences in Endocrine and Immune Responses to an Inflammatory Challenge in Female Sprague Dawley Rats.

Authors:  Tamara S Bodnar; Lesley A Hill; Matthew D Taves; Wayne Yu; Kiran K Soma; Geoffrey L Hammond; Joanne Weinberg
Journal:  Endocrinology       Date:  2015-09-24       Impact factor: 4.736

Review 4.  A controversial role for IL-12 in immune response and bone resorption at apical periodontal sites.

Authors:  Celso Martins Queiroz-Junior; Marcelo José Barbosa Silva; Jôice Dias Corrêa; Mila Fernandes Moreira Madeira; Thiago Pompermaier Garlet; Gustavo Pompermaier Garlet; Fernando Queiroz Cunha; Mauro Martins Teixeira; Tarcília Aparecida da Silva
Journal:  Clin Dev Immunol       Date:  2011-02-16

5.  Polymorphism of interleukin-17 and its relation to mineral density of bones in perimenopausal women.

Authors:  Dariusz Boroń; Seremak-Mrozikiewicz Agnieszka; Kotrych Daniel; Bogacz Anna; Kamiński Adam
Journal:  Eur J Med Res       Date:  2014-12-16       Impact factor: 2.175

6.  Serum matrix metalloproteinase-3 in comparison with acute phase proteins as a marker of disease activity and radiographic damage in early rheumatoid arthritis.

Authors:  Mahmood M T M Ally; Bridget Hodkinson; Pieter W A Meyer; Eustasius Musenge; Mohammed Tikly; Ronald Anderson
Journal:  Mediators Inflamm       Date:  2013-04-07       Impact factor: 4.711

7.  Interleukin-12-mediated expression of matrix metalloproteinases in human periodontal ligament fibroblasts involves in NF-κB activation.

Authors:  Li Miao; Shujun Zhan; Jiyan Liu
Journal:  Biosci Rep       Date:  2017-11-21       Impact factor: 3.840
  7 in total

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