| Literature DB >> 20731705 |
Qing Lan1, Wing-Yan Au, Stephen Chanock, Jovic Tse, Kit-fai Wong, Min Shen, L P Siu, Jeff Yuenger, Meredith Yeager, Howard Dean Hosgood, Mark P Purdue, Raymond Liang, Nathaniel Rothman.
Abstract
The genetic basis of chronic lymphocytic leukemia (CLL) has not been fully elucidated to date. Although it is the most common haematological malignancy in Caucasians, it is uncommon among Asians. A recent genome-wide scan of CLL in Caucasians, which was carried out in the UK, identified six variants showing strong association. We attempted to replicate these findings in 71 patients with CLL and 1273 controls in Hong Kong Chinese. Three of the six variants were significantly associated with CLL. The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study. Polymorphisms in SP140 and ACOXL were also associated with risk of CLL. Further, the mean allele frequencies of the six variants were moderately (59%) to extremely (0.5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese.Entities:
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Year: 2010 PMID： 20731705 PMCID： PMC2980583 DOI： 10.1111/j.1600-0609.2010.01518.x
Source DB: PubMed Journal: Eur J Haematol ISSN： 0902-4441 Impact factor: 2.997