| Literature DB >> 18758461 |
Maria Chiara Di Bernardo1, Dalemari Crowther-Swanepoel, Peter Broderick, Emily Webb, Gabrielle Sellick, Ruth Wild, Kate Sullivan, Jayaram Vijayakrishnan, Yufei Wang, Alan M Pittman, Nicola J Sunter, Andrew G Hall, Martin J S Dyer, Estella Matutes, Claire Dearden, Tryfonia Mainou-Fowler, Graham H Jackson, Geoffrey Summerfield, Robert J Harris, Andrew R Pettitt, Peter Hillmen, David J Allsup, James R Bailey, Guy Pratt, Chris Pepper, Chris Fegan, James M Allan, Daniel Catovsky, Richard S Houlston.
Abstract
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.Entities:
Mesh：
Year: 2008 PMID： 18758461 DOI： 10.1038/ng.219
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330